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Relationship between PI3K/mTOR/RhoA pathway-regulated cytoskeletal rearrangements and phagocytic capacity of macrophages

Bao, H R; Chen, J L; Li, F; Zeng, X L; Liu, X J.
Braz. j. med. biol. res; 53 (7), 2020
The objective of this study was to investigate the relationship between PI3K/mTOR/RhoA signaling regulated cytoskeletal rearrangements and phagocytic capacity of macrophages. RAW264.7 macrophages were divided into four groups; blank control, negative control, PI3K-RNAi, and mTOR-RNAi. The cytoskeletal ch...
Western Blotting, Citoesqueleto/metabolismo, Silenciador del Gen, Vectores Genéticos, Macrófagos/metabolismo, Fagocitosis/fisiología, Fosfatidilinositol 3-Quinasas/metabolismo, Células RAW 264.7, Interferencia de ARN, Reacción en Cadena en Tiempo Real de la Polimerasa, Transducción de Señal, Serina-Treonina Quinasas TOR/metabolismo, Transfección, Proteína de Unión al GTP rhoA/metabolismo
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Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries

Simplicio, Janaina A; Hipólito, Ulisses Vilela; Vale, Gabriel Tavares do; Callera, Glaucia Elena; Pereira, Camila André; Touyz, Rhian M; Tostes, Rita de Cássia; Tirapelli, Carlos R.
Arq. bras. cardiol; 107 (5), 2016
Abstract Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. Objective: To investigate whether acute ethanol intake activates the vascular RhoA/Rho ki...
Antioxidantes/farmacología, Ácido Ascórbico/metabolismo, Ácido Ascórbico/farmacología, Modelos Animales de Enfermedad, Activación Enzimática, Etanol/administración & dosificación, NADPH Oxidasas/efectos de los fármacos, NADPH Oxidasas/metabolismo, Estrés Oxidativo/efectos de los fármacos, Transporte de Proteínas, Ratas Wistar, Proteína de Unión al GTP rhoA/metabolismo
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