Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities
Braz. j. med. biol. res; 51 (10), 2018
Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining ass...
Antineoplásicos Fitogénicos/farmacología, Apoptosis/efectos de los fármacos, Western Blotting, Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Neoplasias del Colon/metabolismo, Neoplasias del Colon/patología, Flavonoides/farmacología, Células HCT116, ARN Interferente Pequeño, Reacción en Cadena en Tiempo Real de la Polimerasa, Proteína p53 Supresora de Tumor/efectos de los fármacos, Proteína p53 Supresora de Tumor/metabolismo