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Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene in Brazilian patients with chronic myeloid leukemia

Costa, Heloísa Zorzi; Pereira, Noemi Farah; kaminski, Luciane; Pasquini, Ricardo; Funke, Vaneuza Araujo Moreira; Mion, Ana Lucia Vieira.
Hematol., Transfus. Cell Ther. (Impr.); 40 (4), 2018
ABSTRACT Introduction: Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene are the leading cause of resistance to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients. Mutations have been detected throughout the extension of the kinase domain of this gene ...
Leucemia Mielógena Crónica BCR-ABL Positiva, Proteínas Tirosina Quinasas, Mutación, Proteínas Proto-Oncogénicas c-bcr, Virus de la Leucemia Murina de Abelson
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AAcute WT1-positive promyelocytic leukemia with hypogranular variant morphology, bcr-3 isoform of PML-RARα and Flt3-ITD mutation: a rare case report

Zhang, Xi; Yang, Cheng; Peng, Xiangui; Chen, Xinghua; Feng, Yimei.
Säo Paulo med. j; 135 (2), 2017
ABSTRACT CONTEXT: Acute promyelocytic leukemia (APL) accounts for 8% to 10% of cases of acute myeloid leukemia (AML). Remission in cases of high-risk APL is still difficult to achieve, and relapses occur readily. CASE REPORT: Here, we describe a case of APL with high white blood cell counts in blood ...
Genes del Tumor de Wilms, Leucemia Promielocítica Aguda/tratamiento farmacológico, Leucemia Promielocítica Aguda/genética, Leucemia Promielocítica Aguda/patología, Mutación, Reacción en Cadena de la Polimerasa, Pronóstico, Proteínas Proto-Oncogénicas c-bcr, Factores de Riesgo, Tirosina Quinasa 3 Similar a fms/genética
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