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MET overexpression and intratumor heterogeneity in esophageal squamous cell carcinoma

Abboud, H S; Camuzi, D; Rapozo, D C; Fernandes, P V; Nicolau-Neto, P; Guaraldi, S; Simão, T A; Ribeiro Pinto, L F; Gonzaga, I M; Soares-Lima, S C.
Braz. j. med. biol. res; 54 (8), 2021
Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic a...
Brasil, Carcinoma de Células Escamosas/genética, Línea Celular Tumoral, Neoplasias Esofágicas/genética, Carcinoma de Células Escamosas de Esófago/genética, Regulación Neoplásica de la Expresión Génica, Neoplasias de Cabeza y Cuello, Proteínas Proto-Oncogénicas c-met/genética, Proteínas Proto-Oncogénicas c-met/metabolismo
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Expression of the c-MET, HGF and VEGF biomarkers in intestinal and diffuse gastric cancer in the Brazilian population: a pilot study for the standardization of the quantitative PCR technique

Cota, Bianca Della Croce Vieira; Lima, Karine Sampaio; Murad, André Márcio; Xavier, Marcelo Antônio Pascoal; Cabral, Mônica Maria Demas Álvares; Coelho, Luiz Gonzaga Vaz.
Appl. cancer res; 37 (), 2017
Background: Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an important role in the pathogenesis of GC. MET gene is a proto-oncogene that encodes a tyro...
Neoplasias Gástricas/genética, Estómago, Reacción en Cadena en Tiempo Real de la Polimerasa, Proto-Oncogenes, Proteínas Proto-Oncogénicas c-met, Factor A de Crecimiento Endotelial Vascular, Biomarcadores de Tumor, Parafina, Regulación de la Población
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