Results: 3

BRAFV600E and KIT immunoexpression in early-stage melanoma

An. bras. dermatol; 94 (4), 2019
Abstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge ...

Indolamina 2, 3-dioxigenase (IDO) em melanoma: regulação frente ao inibidor de BRAF e sua expressão na progressão da doença

Os inibidores de BRAF (iBRAFs) e de MEK (iMEK), inauguraram uma nova classe de medicamentos, a terapia direcionada, no combate ao melanoma metastático. Entretanto, os pacientes adquirem resistência ao tratamento em poucos meses. Além disso, a imunoterapia vem ganhando espaço no tratamento do câncer,...

Macelignan inhibits bee pathogenic fungi Ascophaera apis growth through HOG1 pathway

Braz. j. med. biol. res; 49 (7), 2016
Ascosphaera apis is a bee pathogen that causes bee larvae infection disease, to which treatment is not yet well investigated. The aim of this study was to investigate antifungal susceptibility in vitro against A. apis and to identify a new antifungal agent for this pathogen through minimal inhibitory con...