A via Hippo consiste em uma cascata de serina-treonina quinases que desempenha um papel central na transdução de sinais mecânicos. Em mamíferos, o eixo canônico da via consiste na ativação das quinases MST1 e MST2 (codificadas pelos genes STK4 e STK3, respectivamente) e LATS1 e LATS2. A ativação...
Dentre os sistemas neurais responsáveis pela ingestão dos alimentos, destaca-se a via dopaminérgica mesolímbica que, através da liberação de dopamina nos núcleos de accumbens, desperta prazer e motivação para recompensas químicas e naturais. Esta via de recompensa age através dos receptores d...
Long non-coding RNA (lncRNA) is an essential regulator of carcinogenesis and cancer progression. In the study, we explored the role of lncRNA DLGAP1-AS1 in gastric cancer (GC). qRT-PCR was carried out to detect DLGAP1-AS1 expression in GC tissues and cell lines. CCK-8 assay, EdU assay, and transwell expe...
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as ...
Abstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and m...
Adenoma Pleomórfico/patología,
Biomarcadores de Tumor/análisis,
Carcinoma Adenoide Quístico/patología,
Carcinoma Mucoepidermoide/patología,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/análisis,
Diferenciación Celular,
Estudios Transversales,
Inmunohistoquímica,
Pronóstico,
Proteínas Serina-Treonina Quinasas/análisis,
Valores de Referencia,
Estudios Retrospectivos,
Neoplasias de las Glándulas Salivales/patología
BACKGROUND: Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic prolifer...
Antineoplásicos Fitogénicos/farmacología,
Carcinoma Hepatocelular/tratamiento farmacológico,
Proliferación Celular/efectos de los fármacos,
Estrés del Retículo Endoplásmico/efectos de los fármacos,
Ficusina/farmacología,
Neoplasias Hepáticas/tratamiento farmacológico,
Apoptosis/efectos de los fármacos,
Carcinoma Hepatocelular/patología,
Ficusina/química,
Ficusina/uso terapéutico,
Neoplasias Hepáticas/patología,
Proteínas Serina-Treonina Quinasas/farmacología,
Transducción de Señal/efectos de los fármacos,
Línea Celular Tumoral
This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa ...
Citocinas/sangre,
Modelos Animales de Enfermedad,
Microbioma Gastrointestinal/efectos de los fármacos,
Inflamación/prevención & control,
Lindera/química,
Lipopolisacáridos/sangre,
Hígado/ultraestructura,
Hepatopatías Alcohólicas/diagnóstico por imagen,
Hepatopatías Alcohólicas/prevención & control,
Extractos Vegetales/farmacología,
Raíces de Plantas/química,
Proteínas Serina-Treonina Quinasas/sangre,
Ratas Sprague-Dawley,
Receptor Toll-Like 4/sangre
BACKGROUND: Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. Clinical therapies of gastric cancer remain limited because of uncertainty of mechanisms and shortness of effective medicine. Thus, new drug candidates for gastric cancer treatment is urgently needed. RESULTS: In ...
Antineoplásicos/farmacología,
Apoptosis/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Puntos de Control de la Fase G2 del Ciclo Celular/efectos de los fármacos,
Péptidos y Proteínas de Señalización Intracelular/farmacología,
Proteínas Serina-Treonina Quinasas/farmacología,
Factor de Transcripción SOX9/farmacología,
Neoplasias Gástricas/tratamiento farmacológico,
Proteínas Reguladoras de la Apoptosis/farmacología,
Citocromos/efectos de los fármacos,
Regulación hacia Abajo/efectos de los fármacos,
Citometría de Flujo/métodos,
Neoplasias Gástricas/patología,
Regulación hacia Arriba/efectos de los fármacos,
Western Blotting,
Línea Celular Tumoral,
Reproducibilidad de los Resultados
ABSTRACT Objective: to estimate the prevalence of TaqIA, -141C and rs6280 polymorphisms of the ANKK1, DRD2 and DRD3 genes and evaluate their association with the occurrence of metabolic syndrome in patients with refractory schizophrenia. Method: cross-sectional study conducted in the Extended Western R...
SUMMARY Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identi...
Diabetes Mellitus/clasificación,
Diabetes Mellitus/genética,
Predisposición Genética a la Enfermedad,
Pruebas Genéticas,
Genotipo,
Quinasas del Centro Germinal,
Factor Nuclear 1-alfa del Hepatocito/genética,
Factor Nuclear 4 del Hepatocito/genética,
Mutación,
Linaje,
Proteínas Serina-Treonina Quinasas/genética
