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Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation

Li, Ning; Zhou, Qianyin; Yi, Zhang; Zhang, Huan; Zhou, Dai.
Biol. Res; 56 (), 2023
BACKGROUND: Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be discovered. METHODS: To explore the regulatory mechanisms of human SSCs, we analyzed pub...
Testículo/metabolismo, Ubiquitina-Proteína Ligasas/metabolismo, Ubiquitinas/metabolismo, Proteínas Supresoras de la Señalización de Citocinas/metabolismo, Espermatogénesis/fisiología, Proteínas Represoras/metabolismo, Oxigenasas de Función Mixta/metabolismo, Proliferación Celular, Línea Celular, Apoptosis
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Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN)

Tirone, Nelson Ranieri; Campos, Carolina Guissoni; Ferreira, Kézia Jesus Aguiar; Stark, Léticia Montes; Vieira, Jéssica Ferreira; Murta, Eddie Fernando Cândido; Michelin, Márcia Antoniazi.
Rev. bras. ginecol. obstet; 43 (9), 2021
Abstract Objective The aim of the present study was to compare the local and systemic expression of the factors linked to the interferon alpha (IFN-α) activation pathway in different degrees of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods A total of 128 patients with CIN...
31574/genética, Interferón-alfa, Proteínas Supresoras de la Señalización de Citocinas/metabolismo, Neoplasias del Cuello Uterino/genética
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