Abstract Introduction Acute myeloid leukemia (AML) is a heterogeneous disease and approximately one-third of its carriers do not have evident genetic abnormalities. The mutation of specific molecular markers, such as fms-like tyrosine kinase 3 (FTL3) internal tandem duplication (ITD), FLT3 tyrosine kina...
ABSTRACT Introduction: Treatment-free remission (TFR) is a new goal of chronic myeloid leukemia (CML) therapy. TFR is feasible when the patient has achieved a deep and stable molecular response and met the criteria required to ensure its success. Treatment discontinuation should not be proposed to the C...
Câncer é a denominação atribuída a um conjunto de doenças que são responsáveis pela segunda maior causa de morte no Brasil e no mundo. A quimioterapia figura entre uma das estratégias utilizadas para o tratamento e cura do câncer, sendo amplamente empregada em estratégias terapêuticas isolada...
Histona Desacetilasa 6/antagonistas & inhibidores,
Proteínas Tirosina Quinasas/antagonistas & inhibidores,
Neoplasias/tratamiento farmacológico,
Quimioterapia/clasificación,
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos,
Espectrometría de Masas/métodos,
Espectroscopía de Resonancia Magnética con Carbono-13,
Inhibidores de Histona Desacetilasas/efectos adversos,
Preparaciones Farmacéuticas,
Quimioterapia/instrumentación,
Tubulina (Proteína)
El carcinoma hepatocelular (CHC) es una de las principales causas de morbilidad y mortalidad
relacionada con el cáncer en todo el mundo. La mayoría de los casos ocurren en un contexto de
cirrosis o hepatitis crónica. Los pacientes con CHC avanzado no disponían de terapias efectivas
hasta el 2008, cua...
Objetivo: Avaliar o impacto econômico da descontinuação do tratamento da leucemia mieloide
crônica (LMC) com inibidores da tirosina quinase (ITQs) em primeira ou segunda linha. Métodos:
O modelo incluiu pacientes com diagnóstico de LMC em tratamento com ITQs que iniciaram o tratamento até 2012, em...
Seguro, Fernanda Salles;
Silva, Carolina Maria Pinto Domingues Carvalho;
Moura, Carla Maria Boquimpani de;
Conchon, Monika;
Fogliatto, Laura;
Funke, Vaneuza Araujo Moreira;
Abdo, André;
Macedo, Ariane Vieira Scarlatelli;
Santos, Marilia Harumi Higushi dos;
Saraiva, José Francisco Kerr.
ABSTRACT This manuscript summarizes the results of the consensus meeting composed of hematologists and cardiologists to establish recommendations for the prevention and follow-up of cardiovascular (CV) risk in patients with chronic myeloid leukemia (CML) treated with BCR-ABL tyrosine kinase inhibitors (T...
Introduction Squamous carcinoma is the commonest malignancy of the head and neck region. It is associated with high morbidity and mortality. Epidermal growth factor receptor (EGFR) regulates downstream signaling pathways through its tyrosine kinase (TK) domains that play a role in cell proliferation and ...
INTRODUCCIÓN: El presente dictamen expone la evaluación de la eficacia y seguridad del esquema ibrutinib + corticoides, comparado con los esquemas basados en corticoides + inmunosupresores, para el tratamiento de pacientes adultos con enfermedad de injerto contra huésped crónica (cGVHD) post-trasplan...
Resumen Se presentan dos casos clínicos de pacientes con leucemia mieloide crónica en fase acelerada, hospitalizados para inicio de terapia dirigida con inhibidores de tirosina cinasa (dasatinib). Posteriormente se determina la presencia de sangrado intraparenquimatoso a sistema nervioso central. Para ...
ABSTRACT Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells, participating in their expansion, differe...
