Santos, Priscila P. dos;
Rafacho, Bruna P. M;
Gonçalves, Andrea F;
Pires, Vanessa C. M;
Roscani, Meliza G;
Azevedo, Paula S;
Polegato, Bertha F;
Minicucci, Marcos F;
Fernandes, Ana Angélica H;
Tanni, Suzana E;
Zornoff, Leonardo A. M;
Paiva, Sergio A. R. de.
Resumo Fundamento: A vitamina D (VD) tem um importante papel na função cardíaca. No entanto, a vitamina exerce uma curva "dose-resposta" bifásica na fisiopatologia cardiovascular e pode causar efeitos deletérios, mesmo em doses não tóxicas. A VD exerce suas funções celulares ligando-se ao seu r...
Abstract The Inhibitor of Growth (ING) gene family is a group of tumor suppressor genes that play important roles in cell cycle control, senescence, DNA repair, cell proliferation, and apoptosis. However, inactivation and downregulation of these proteins have been related in some neoplasms. The present s...
Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies. Participants of the cohort Pediatric Brain Tumor Atlas: CBTTC (CBTTC cohort), were randomly divided into training and validation cohorts. In...
Abstract Background: Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic...
BACKGROUND: Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remai...
Abstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and m...
Adenoma Pleomórfico/patología,
Biomarcadores de Tumor/análisis,
Carcinoma Adenoide Quístico/patología,
Carcinoma Mucoepidermoide/patología,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/análisis,
Diferenciación Celular,
Estudios Transversales,
Inmunohistoquímica,
Pronóstico,
Proteínas Serina-Treonina Quinasas/análisis,
Valores de Referencia,
Estudios Retrospectivos,
Neoplasias de las Glándulas Salivales/patología
Retinoblastoma is a childhood ocular tumor often caused by the biallelic inactivation of the RB1 gene affecting children up to 5 years of age. A retinoblastoma protein (pRB), encoded by the tumor suppressor gene RB1, is responsible for the regular progression of the G1 phase to the phase S of the cell cy...
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac ma...
Proteínas Adaptadoras Transductoras de Señales/antagonistas & inhibidores,
Proteínas Adaptadoras Transductoras de Señales/efectos de los fármacos,
Proteínas Adaptadoras Transductoras de Señales/fisiología,
Angiotensina II/farmacología,
Western Blotting,
Cardiomiopatía Dilatada/patología,
Cardiomiopatía Dilatada/fisiopatología,
Proteínas de Ciclo Celular,
Diferenciación Celular,
Transdiferenciación Celular/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ecocardiografía,
Ratones Endogámicos BALB C,
Microscopía Fluorescente,
Miofibroblastos/efectos de los fármacos,
Miofibroblastos/fisiología,
Fosfoproteínas/antagonistas & inhibidores,
Fosfoproteínas/fisiología,
Ratas Sprague-Dawley,
Porcinos
Abstract Objective The aim of the present study was to analyze the expression of the CD63, S100A6, and GNB2L1genes, which participate in mechanisms related to the complex pathophysiology of endometriosis. Methods A case-control study was conducted with 40 women who were diagnosed with endometriosis, ...
Apoptosis/genética,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/genética,
Proliferación Celular/genética,
Endometriosis/genética,
Endometriosis/patología,
Expresión Génica,
Proteínas de Neoplasias/genética,
Neovascularización Patológica/genética,
Receptores de Cinasa C Activada/genética,
Proteína A6 de Unión a Calcio de la Familia S100/genética,
Tetraspanina 30/genética
ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and metho...
Regiones no Traducidas/genética,
Proteínas de Ciclo Celular/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica/genética,
MicroARNs/antagonistas & inhibidores,
MicroARNs/fisiología,
Invasividad Neoplásica,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/mortalidad,
Neoplasias de la Próstata/patología,
Proteínas de Unión al ARN/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteínas Supresoras de Tumor/metabolismo,
Regulación hacia Arriba
