LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

miR-483-5p promotes prostate cancer cell proliferation and invasion by targeting RBM5

Yang, Zhi-Gang; Ma, Xu-Dong; He, Zhao-Hui; Guo, Ying-xin.

Int. braz. j. urol; 43 (6), 2017

ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and metho...

Regiones no Traducidas/genética, Proteínas de Ciclo Celular/metabolismo, Línea Celular Tumoral, Proliferación Celular/genética, Proteínas de Unión al ADN/metabolismo, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica/genética, MicroARNs/antagonistas & inhibidores, MicroARNs/fisiología, Invasividad Neoplásica, Neoplasias de la Próstata/genética, Neoplasias de la Próstata/mortalidad, Neoplasias de la Próstata/patología, Proteínas de Unión al ARN/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa, Proteínas Supresoras de Tumor/metabolismo, Regulación hacia Arriba

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Neutral space analysis for a Boolean network model of the fission yeast cell cycle network

BACKGROUND: Interactions between genes and their products give rise to complex circuits known as gene regulatory networks (GRN) that enable cells to process information and respond to external stimuli. Several important processes for life, depend of an accurate and context-specific regulation of gene exp...