Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its i...
SUMMARY OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinom...
Hochmann Valls, Jimena Paola;
Parietti Pintos, Felipe Álvaro;
Martínez Cazarre, Jennyfer;
López Royes, Ana Clara;
Carreño Sastre, Mara;
Quijano Herrera, Celia Lía;
Boccardo, Enrique;
Sichero, Laura;
Möller Rodríguez, Matías Nicolás;
Mirazo Villar, Santiago;
Arbiza Rodonz, Juan Ramón.
BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) that possess a high transformation potential in culture cells when transduced simu...
Experiments were conducted to determine if the follicle-stimulating hormone (FSH) receptor binding inhibitor (FRBI) impacts the expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) in ovaries and blood, as well as expressions of follicle...
Western Blotting,
Proteínas de Unión al ADN/sangre,
Proteínas de Unión al ADN/metabolismo,
Hormona Folículo Estimulante/metabolismo,
Proteínas Nucleares/sangre,
Proteínas Nucleares/metabolismo,
Neoplasias Ováricas/metabolismo,
Fosfohidrolasa PTEN/sangre,
Fosfohidrolasa PTEN/metabolismo,
Fosforilación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Receptores de HFE/antagonistas & inhibidores,
Factores de Transcripción,
Activación Transcripcional/genética,
Regulación hacia Arriba
Background: TRF2 (telomeric repeat binding factor 2) is an essential component of the telomere-binding protein complex shelterin. TRF2 induces the formation of a special structure of telomeric DNA and counteracts activation of DNA damage-response pathways telomeres. TRF2 has a poorly characterized linker...
Anticuerpos/metabolismo,
Anticuerpos/aislamiento & purificación,
Formación de Anticuerpos,
Proteína 2 de Unión a Repeticiones Teloméricas/metabolismo,
Escherichia coli/metabolismo,
Inmunoprecipitación,
Inmunohistoquímica,
Proteína 2 de Unión a Repeticiones Teloméricas/genética,
Clonación Molecular,
Plásmidos,
Western Blotting,
Proteínas Recombinantes/metabolismo,
Lámina Nuclear,
Nucleoproteínas,
Cromosomas,
Proteínas de Unión al ADN/metabolismo
Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1-8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In ...
Biomarcadores de Tumor/genética,
Biomarcadores de Tumor/metabolismo,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/metabolismo,
Neoplasias Colorrectales/patología,
ADN Helicasas,
Proteínas de Unión al ADN/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Pronóstico,
Transactivadores,
Factores de Transcripción/genética,
Factores de Transcripción/metabolismo
BACKGROUND: Neuroblastoma (NB) represents the most common extracranial solid tumor in children. Accumulating evidence shows that microRNAs (miRs) play an important role in the carcinogenesis of NB. Here, we investigated the biological function of miR-1247 in NB in vitro. METHODS/RESULTS: We found miR-12...
Proteínas de Unión al ADN/metabolismo,
MicroARNs/metabolismo,
Neuroblastoma/metabolismo,
Proteínas de Unión al ARN/metabolismo,
Proliferación Celular/genética,
Proteínas de Unión al ADN/genética,
MicroARNs/genética,
Neuroblastoma/genética,
Neuroblastoma/patología,
Proteínas de Unión al ARN/genética,
Preescolar,
Ensayo de Unidades Formadoras de Colonias,
Regulación hacia Abajo,
Citometría de Flujo,
Regulación Neoplásica de la Expresión Génica,
Fenotipo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Tiempo,
Células Tumorales Cultivadas
ABSTRACT Objective: miR-483-5p has been identified as a miRNA oncogene in certain cancers. However, its role in prostate cancer has not been sufficiently investigated. In this study, we investigated the role of miR-483-5p in prostate cancer and examined RBM5 regulation by miR-483-5p. Material and metho...
Regiones no Traducidas/genética,
Proteínas de Ciclo Celular/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica/genética,
MicroARNs/antagonistas & inhibidores,
MicroARNs/fisiología,
Invasividad Neoplásica,
Neoplasias de la Próstata/genética,
Neoplasias de la Próstata/mortalidad,
Neoplasias de la Próstata/patología,
Proteínas de Unión al ARN/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteínas Supresoras de Tumor/metabolismo,
Regulación hacia Arriba
Mechanisms to protect organisms from the consequences of DNA damage include the tumor suppressor p53 pathway. p53 protein binds specifically to a DNA consensus sequence to induce growth inhibitory genes or nonspecifically to damaged sites leading to DNA repair or apoptosis. While p53 protein is susceptib...
