LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

An epidermal growth factor motif of developmental endothelial locus 1 protein inhibits efficient angiogenesis in explanted squamous cell carcinoma in vivo

Kitano, Hisataka; Mamiya, Atsushi; Ishikawa, Tomomi; Fujiwara, Yusuke; Masaoka, Yoh; Miki, Toshio; Hidai, Chiaki.

Rev. invest. clín; 73 (1), 2021

ABSTRACT Background: Cancer gene therapy using a nonviral vector is expected to be repeatable, safe, and inexpensive, and to have long-term effectiveness. Gene therapy using the E3 and C1 (E3C1) domain of developmental endothelial locus-1 (Del1) has been shown to improve prognosis in a mouse transplante...

Secuencias de Aminoácidos, Proteínas de Unión al Calcio/genética, Proteínas de Unión al Calcio/uso terapéutico, Carcinoma de Células Escamosas/irrigación sanguínea, Carcinoma de Células Escamosas/terapia, Moléculas de Adhesión Celular/genética, Moléculas de Adhesión Celular/uso terapéutico, Dominio Discoidina/genética, Factor de Crecimiento Epidérmico/genética, Factor de Crecimiento Epidérmico/uso terapéutico, Terapia Genética, Ratones Desnudos, Trasplante de Neoplasias, Neovascularización Patológica/terapia, Células Tumorales Cultivadas

Fulltext

Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse

SUMMARY OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients' quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polym...