Effects of Rab7 gene up-regulation on renal fibrosis induced by unilateral ureteral obstruction
Braz. j. med. biol. res; 53 (4), 2020
Rab7, an important member of the Rab family, is closely related to autophagy, endocytosis, apoptosis, and tumor suppression but few studies have described its association with renal fibrosis. In the early stage, our group studied the effects of Rab7 on production and degradation of extracellular matrix i...
Autofagia/fisiología, Fibrosis, Riñón/patología, Enfermedades Renales/etiología, Ratones Noqueados, ARN/aislamiento & purificación, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Transducción de Señal, Regulación hacia Arriba, Obstrucción Ureteral/complicaciones, Proteínas de Unión al GTP rab/genética, Proteínas de Unión al GTP rab/metabolismo