Cavalcanti, Bruno Coêlho;
Silva, Cecília Rocha da;
Andrade Neto, João Batista de;
Josino, Maria Aparecida Alexandre;
Sá, Lívia Gurgel do Amaral Valente;
Silva, Antônio Adailson de Sousa;
Barreto, Francisco Stefânio;
Ferreira, José Roberto de Oliveira;
Magalhães, Hemerson Iury Ferreira;
Vieira, Ícaro Gusmão Pinto;
Brito, Débora Hellen Almeida;
Ricardo, Nágila Maria Pontes Silva;
Barroso, Fátima Daiana Dias;
Costa, Érica Rayanne Mota da;
Nobre Júnior, Hélio Vitoriano;
Moraes, Manoel Odorico de.
Objectives: The purpose of this study was to evaluate the mutagenic potential of fluoxetine and fluoxetine-galactomannan. Methods: Chromosomal aberration test and Salmonella typhimurium/microsome mutagenicity assay. Results: The results showed that fluoxetine (250 μg/mL) can cause chromosomal breaks of ...
Aim: This study aimed to investigate whether non-ionizing radiation emitted by smartphones is likely to cause genotoxic effects on oral epithelial cells. Methods: Thirty adults were distributed into two groups according to the mobile phone brand used, namely Samsung (Sam...
Abstract Dexchlorpheniramine is a first-generation classical antihistamine, clinically used to treat allergies. The main objective of our study was to evaluate the effects of the dexchlorpheniramine reference standard (DCPA Ref. St) and a pharmaceutical formula on DNA in human peripheral blood mononuclea...
Abstract Fridericia caudigera and Cuspidaria convoluta (Bignoniaceae) species, which grow in the northwest of Argentina, have shown antibacterial effect against strains isolated from skin infections, and each one displayed synergism with commercial antibiotics. The aims of this work were to evaluate the ...
ABSTRACT Objective: To evaluate genotoxicity of zinc oxide, P. A. calcium hydroxide, mineral trioxide aggregate and an iodoform paste using comet assay on human lymphocytes. Material and Methods: Two positive controls were used: methyl-methanesulfonate for the P.A. calcium hydroxide and mineral trioxid...
Abstract Introduction: Formaldehyde is a substance widely used in the industry; however, it is classified as mutagenic and carcinogenic to humans. In order to determine the risk of workers who are occupationally exposed to formaldehyde, it is necessary to monitor its environmental concentration levels a...
The present study tested a comet assay that was modified for compatibility with Giemsa staining to assess the drug genotoxicity in the peripheral blood of rats. We analysed the peripheral blood of 16 female Wistar rats (N=8 rats/group) from a control group and from a group that was treated with an intrap...
BACKGROUND:
Taraxacum species (commonly known as dandelion) used as herbal medicine have been reported to exhibit an antiproliferative effect on hepatoma cells and antitumor activity in non-small-cell lung cancer cells. Although several investigations have demonstrated the safety of Taraxacum officinale,...
Seguridad,
Pruebas de Mutagenicidad,
Suero,
Urinálisis,
Pruebas de Toxicidad Subaguda,
Ratas Sprague-Dawley,
Cromatografía Líquida de Alta Presión,
Flavonoides/análisis,
Fenol/análisis,
Taraxacum/química,
Medicina de Hierbas,
35514,
Proliferación Celular/efectos de los fármacos,
Técnicas de Cultivo de Tejidos/métodos,
Extractos Vegetales/toxicidad,
Taraxacum/toxicidad
The melamine and cyanuric acid (CA) complex has been suggested to cause the toxic effects observed in melamine-contaminated food or milk. However, the cytotoxic and genotoxic effects of co-exposure to melamine and CA are not fully clear. Therefore, the cytotoxic effects of melamine and CA were first exam...
Objective: The study’s goal has been to analyze if environmental or occupational exposure to pesticides can produce changes in pregnant women living in a countryside municipality. Methods: The participants of this study were twenty-three pregnant women, who both answered a questionnaire and donated bio...
