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Regulation of Notch1 and Foxp1 by MiR-34a in psoriasis vulgaris

Wang, Huiqin; Zhang, Xiaoling; Bu, Juan; Wu, Weidong.
Int. j. morphol; 40 (3), 2022
SUMMARY: This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in the development of psoriasis vulgaris. RT-PCR was used to compare the levels of miR-34a in the skin lesions of 20 patients with psoriasis vulgaris and 20 normal skin tissues. Immunohistochemistry was used to detect the...
Psoriasis/genética, Psoriasis/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Receptor Notch1/genética, Receptor Notch1/metabolismo, Factores de Transcripción Forkhead/genética, Factores de Transcripción Forkhead/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Inmunohistoquímica, Transfección, Western Blotting
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Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity

Alatas, Emine Tugba; Kara, Murat; Dogan, Gursoy; Akın Belli, Aslı.
An. bras. dermatol; 95 (6), 2020
Abstract Background: In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients including a large number of mi-RNA panels are scarce. Objective: The authors aimed to assess mi-RNA exp...
Biomarcadores, Estudios de Casos y Controles, MicroARNs/genética, Psoriasis/genética, Reacción en Cadena en Tiempo Real de la Polimerasa
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Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study

Hayran, Yıldız; Allı, Nuran; Uysal, Pınar İncel; Çandar, Tuba.
An. bras. dermatol; 95 (1), 2020
Abstract Background: Cytochrome P450 2J2 is mostly expressed in extrahepatic tissues; it metabolizes arachidonic acid to epoxyeicosatrienoic acids, with various cardio protective and anti-inflammatory effects. CYP2J2 polymorphism has been identified as a risk factor for cardiovascular diseases, but its ...
Edad de Inicio, Enfermedades Cardiovasculares/genética, Estudios de Casos y Controles, Sistema Enzimático del Citocromo P-450/genética, Frecuencia de los Genes, Estudios de Asociación Genética, Genotipo, Persona de Mediana Edad, Reacción en Cadena de la Polimerasa, Polimorfismo Genético, Psoriasis/genética, Factores de Riesgo, Estadísticas no Paramétricas, Turquía
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Lack of association between mutation in IL36RN and palmoplantar pustular psoriasis in Chinese patients

Xiaoling, Yu; Dan, Shu; Hongzhong, Jin.
An. bras. dermatol; 94 (6), 2019
Abstract Background: Palmoplantar pustulosis is considered to be a localized pustular psoriasis confined to the palms and soles. Mutation of the IL36RN gene, encoding interleukin-36 receptor antagonist (IL-36Ra), is associated with generalized pustular psoriasis, but IL36RN mutations in Chinese palmopla...
Análisis del Polimorfismo de Longitud de Fragmentos Amplificados, Pueblo Asiatico/genética, China, Dermatosis del Pie/genética, Dermatosis del Pie/patología, Estudios de Asociación Genética, Dermatosis de la Mano/genética, Dermatosis de la Mano/patología, Heterocigoto, Interleucinas/genética, Mutación, Fenotipo, Psoriasis/genética, Psoriasis/patología, Análisis de Secuencia de ADN, Estadísticas no Paramétricas
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The role of GNLY gene polymorphisms in psoriasis pathogenesis

Ermis, Esra; Celik, Sevim Karakas; Solak, Nilgun; Genc, Gunes Cakmak; Dursun, Ahmet.
An. bras. dermatol; 94 (2), 2019
Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granuly...
Alelos, Antígenos de Diferenciación de Linfocitos T/genética, Estudios de Casos y Controles, Expresión Génica, Genotipo, Polimorfismo Genético/genética, Sustancias Protectoras, Psoriasis/etiología, Psoriasis/genética, Índice de Severidad de la Enfermedad
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Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population

Jorge, Maria Augusta; Gonzaga, Heron Fernando de Sousa; Tomimori, Jane; Picciani, Bruna Lavinas Sayed; Barbosa, Calógeras Antônio.
An. bras. dermatol; 92 (6), 2017
Abstract: Background: An oral condition associated to psoriasis is benign migratory glossitis. The review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the Brazilian population. Objective: This research ...
Brasil/epidemiología, Glositis Migratoria Benigna/epidemiología, Glositis Migratoria Benigna/genética, Prevalencia, Psoriasis/epidemiología, Psoriasis/genética, Estudios Retrospectivos, Factores de Riesgo, Distribución por Sexo
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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey

Izmirli, Muzeyyen; Sen, Bilge Bulbul; Rifaioglu, Eminenur; Gogebakan, Bulent; Aldemir, Ozgur; Sen, Tuba; Ekiz, Ozlem; Alptekin, Davut.
An. bras. dermatol; 91 (5), 2016
Abstract: Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocystei...
Metilenotetrahidrofolato Reductasa (NADPH2)/genética, Polimorfismo Genético/genética, Psoriasis/enzimología, Polimorfismo de Longitud del Fragmento de Restricción/genética, Psoriasis/genética, Factores de Riesgo, Turquía
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Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review

Picciani, Bruna Lavinas Sayed; Domingos, Tábata Alves; Teixeira-Souza, Thays; Santos, Vanessa de Carla Batista dos; Gonzaga, Heron Fernando de Sousa; Cardoso-Oliveira, Juliana; Gripp, Alexandre Carlos; Dias, Eliane Pedra; Carneiro, Sueli.
An. bras. dermatol; 91 (4), 2016
Abstract: Geographic tongue is a chronic, inflammatory, and immune-mediated oral lesion of unknown etiology. It is characterized by serpiginous white areas around the atrophic mucosa, which alternation between activity, remission and reactivation at various locations gave the names benign migratory gloss...
Glositis Migratoria Benigna/genética, Glositis Migratoria Benigna/patología, Psoriasis/genética, Psoriasis/patología, Lengua/patología, Biopsia, Marcadores Genéticos, Glositis Migratoria Benigna/complicaciones, Glositis Migratoria Benigna/terapia, Antígenos HLA/análisis, Inmunohistoquímica, Ilustración Médica, Psoriasis/complicaciones, Lengua Fisurada/patología
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Dermatopatías [Comentarios del director]
Dermatopathies [Comments of the director]

Honeyman Mauro, Juan.
Rev. chil. dermatol; 17 (2), 2001
Psoriasis/genética, Acné Vulgar/tratamiento farmacológico, Envejecimiento/inmunología, Linfocitos T/fisiología, Linfocitos T CD8-positivos/fisiología, Linfocitos B/fisiología, Sistema Inmunológico/fisiología, Retinoides/farmacología, Retinoides/efectos adversos, Acné Vulgar/etiología, Acné Vulgar/complicaciones, Acné Vulgar/psicología, Ansiedad, Fototerapia, Cicatriz/cirugía, Cicatriz/terapia