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Use of biorelevant dissolution media in dissolution tests as a predictive method of oral bioavailability

Lemos, Hemilliano de; Prado, Livia Deris; Rocha, Helvécio Vinícius Antunes.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are no...
Disolución, Equivalencia Terapéutica, Liberación de Fármacos, Preparaciones Farmacéuticas/análisis, Publicaciones/clasificación, Técnicas In Vitro/instrumentación
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A review on medicinal plants used for treating ototoxicity and acoustic trauma induced hearing loss

Mahmoudian-sani, Mohammad-Reza; Sheikhshabani, SomayehHashemi; Mirfakhar, Farzaneh Sadat; Asgharzade, Samira.
Braz. J. Pharm. Sci. (Online); 55 (), 2019
Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processe...
Ototoxicidad/patología, Plantas Medicinales, Pérdida Auditiva Provocada por Ruido/clasificación, Quimioterapia/métodos, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos, Pérdida Auditiva/complicaciones, Estrés Oxidativo, Heridas y Lesiones, Publicaciones/clasificación, Sordera
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