Studies on the recombinant production and anticancer activity of thermostable L- asparaginase I from Pyrococcus abyssi
Braz. j. biol; 82 (), 2022
L-Asparaginase catalysing the breakdown of L-Asparagine to L-Aspartate and ammonia is an enzyme of therapeutic importance in the treatment of cancer, especially the lymphomas and leukaemia. The present study describes the recombinant production, properties and anticancer potential of enzyme from a hypert...
Antineoplásicos/farmacología, Asparaginasa/biosíntesis, Asparaginasa/farmacología, Células CACO-2, Estabilidad de Enzimas, Escherichia coli/genética, Concentración de Iones de Hidrógeno, Simulación del Acoplamiento Molecular, Pyrococcus abyssi/enzimología, Proteínas Recombinantes/biosíntesis, Proteínas Recombinantes/farmacología, Especificidad por Sustrato