SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...
Cicatrización de Heridas/efectos de los fármacos,
Quemaduras/tratamiento farmacológico,
Piel,
Modelos Animales de Enfermedad,
Técnicas In Vitro,
Fibroblastos,
Fosfatidilinositol 3-Quinasas,
Proteínas Proto-Oncogénicas c-akt,
Naftoquinonas/administración & dosificación,
Ratones Endogámicos C57BL,
Naftoquinonas/farmacología,
Proliferación Celular/efectos de los fármacos
Abstract This study was carried out to evaluate the effect of Glutamine, as a dipeptide or a free amino acid form, on the progression of burn injuries in rats. Thirty male Wistar rats were burned with a comb metal plate heated in boiling water (98 °C) for three minutes, creating four rectangular full-th...
Abstract Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence of the effectiveness and safety of the use of aloe vera in the treatment of burns. A systematic review was carried out on the ...
ABSTRACT Purpose This study aimed to elaborate a hydrogel constituted by carboxymethyl chitosan (CMC), hyaluronic acid (HA) and silver (Ag) and to evaluate its healing effect on partial-thickness burn wounds experimentally induced in rats. Methods CMC was obtained by chitosan reacting with monochloroac...
Souza, T F G;
Pierdoná, T M;
Macedo, F S;
Aquino, P E A;
Rangel, G F P;
Duarte, R S;
Silva, L M A;
Viana, G S B;
Alves, A P N N;
Montenegro, R C;
Wilke, D V;
Silveira, E R;
Alencar, N M N.
It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. Ha...
INTRODUCCIÓN: Se puede formar tejido cicatricial después de una cirugía, trauma o diversas afecciones inflamatorias. Las cicatrices pueden crear muchas funciones adversas, efectos cosméticos y estructurales, y a veces efectos psicológicos, eso puede afectar la vida diaria de los pacientes (Kerwin et...
OBJETIVO: Esse estudo tem por objetivo analisar as interações medicamentosas em prescrições de pacientes pediátricos do Centro de Tratamento de Queimados.
MÉTODO: Trata-se de um estudo analítico de orientação retrospectiva, com análise das prescrições quanto à segurança e interações medic...
Abstract This study aims to evaluate tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments. This is a systematic literature review and meta-analysis of randomized clinical trials performed according to the Preferred Reporting Items for Systematic Reviews and...
O meropenem é um carbapenêmico de amplo espectro e alta potência, largamente prescrito para tratamento de infecções graves causadas por bactérias sensíveis gram-negativas em pacientes críticos internados em Unidades de Terapia Intensiva. O objetivo do presente estudo foi avaliar a efetividade do ...
A dor e o sofrimento estão associados com queimaduras, trazem efeitos fisiológicos e emocionais adversos, principalmente em crianças. O controle adequado
da dor é um fator importante na melhora dos resultados clínicos. Este estudo tem como objetivo identificar na literatura os princípios ativos mai...
