LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Cordycepin prevents the esophageal stricture formation in the alkali-burn rat model by exerting anti-inflammatory and antifibrotic effects

Ercan, Gulcin; Altinel, Yuksel; Karagulle, Onur Olgac; Yiğitbaş, Hakan; Hacım, Nadir Adnan; Meriç, Serhat; Buğdaycı, Nihat; Tartar, Rumeysa Ilbar; Biltekin, Burcu; Yavuz, Erkan; Gulcicek, Osman Bilgin; Solmaz, Ali; Çelik, Atilla.

Acta cir. bras; 36 (3), 2021

ABSTRACT Purpose To investigate the efficacy of cordycepin, an adenosine analogue, on prevention of esophageal damage and stricture formation due to esophageal caustic burns in rat model comparing with prednisolone. Methods Caustic esophageal burn was introduced by 37.5% of NaOH to distal esophagus. Th...

Álcalis/uso terapéutico, Antiinflamatorios/uso terapéutico, Quemaduras Químicas/tratamiento farmacológico, Cáusticos/toxicidad, Desoxiadenosinas, Estenosis Esofágica/inducido químicamente, Estenosis Esofágica/tratamiento farmacológico, Estenosis Esofágica/prevención & control, Ratas Wistar, Factor A de Crecimiento Endotelial Vascular/uso terapéutico, Cáusticos/uso terapéutico

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Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury

Ilhan, Abdullah; Yolcu, Umit; Oztas, Emin; Erdem, Uzeyir.

Arq. bras. oftalmol; 81 (3), 2018

ABSTRACT Purpose: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. Methods: Eighteen male rats were ...

Antioxidantes/uso terapéutico, Quemaduras Químicas/tratamiento farmacológico, Sustancias para la Guerra Química, Modelos Animales de Enfermedad, Lesiones Oculares/inducido químicamente, Lesiones Oculares/tratamiento farmacológico, Mecloretamina, Proantocianidinas/uso terapéutico, Distribución Aleatoria, Ratas Sprague-Dawley, Ubiquinona/análogos & derivados, Ubiquinona/uso terapéutico

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Effects of chitin and sepia ink hybrid sponge on the healing of burning wound rats and its impact on macrophages in vitro

Zhang, Wei; Wang, Yan; Sui, Xianxian; Sun, Yulin; Chen, Daohai.

Acta cir. bras; 31 (2), 2016

PURPOSE: To detect whether chitin and sepia ink sponge (CS) can promote wound healing and elevate impact of CS on phagocytosis ability of macrophages. METHODS: Forty-eight rats were assigned to four groups: Normal group (Normal), negative control group (Con), chitin and sepia ink sponge group (CS) and po...

Quemaduras Químicas/tratamiento farmacológico, Quitina/farmacología, Macrófagos/efectos de los fármacos, Sepia, Cicatrización de Heridas/efectos de los fármacos, Quitina/uso terapéutico, Citocinas/efectos de los fármacos, Citocinas/metabolismo, Modelos Animales de Enfermedad, Hidroxiprolina/metabolismo, Tinta, Macrófagos/metabolismo, Metaloproteinasa 1 de la Matriz/efectos de los fármacos, Fagocitosis/efectos de los fármacos, Distribución Aleatoria, Ratas Wistar

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