Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 8

Analysis of the toxicological and pharmacokinetic profile of Kaempferol-3-O-β-D-(6"-E-p-coumaryl) glucopyranoside - Tiliroside: in silico, in vitro and ex vivo assay

Sousa, A P; Fernandes, D A; Ferreira, M D L; Cordeiro, L V; Souza, M F V; Pessoa, H L F; Oliveira Filho, A A; Sá, R C S.
Braz. j. biol; 83 (), 2023
Abstract Tiliroside is a glycosidic flavonoid present in many plants species including Helicteres velutina K. Schum (Malvaceae sensu lato), commonly known in Brazil as "pitó". This molecule has been shown to have many biological activities, however no study has been carried out to investigate the toxici...
Brasil, Simulación por Computador, Flavonoides, Quempferoles/toxicidad, Extractos Vegetales
Fulltext

Network pharmacology strategy to investigate the pharmacological effects of Suanzaoren Decoction on insomnia

Weng, Xiaojian; Jiang, Jimin; Li, Hailong; Tan, Yi.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Suanzaoren Decoction (SZRD) is an ancient prescription used in the treatment of insomnia. This study aimed to investigate the components and targets of SZRD in treating insomnia. First, the compounds of five herbs in SZRD were collected from the Traditional Chinese Medicine Systems Pharmacology ...
Trastornos del Inicio y del Mantenimiento del Sueño/clasificación, Extractos Vegetales/farmacología, Quercetina/efectos adversos, Quempferoles/efectos adversos, Pentobarbital/análisis
Fulltext

Estudo do potencial antiviral sobre Sars Cov-2 dos compostos identificados nas folhas do extrato bruto de Eugenia pyriformis

Mendonça, Juliana Aparecida; Rahal, Isabelle Luiz; Silva, Gabriela Catuzo Canônico; Gazim, Zilda Cristiani; Gonçalves, Daniela Dib; Trevisani, Adriane Cordeiro; Laginestra, Bruna de Fatima Antunes; Ferreira, Larissa Rafaela de Paula; Piau Junior, Ranulfo.
Arq. ciências saúde UNIPAR; 26 (3), 2022
Eugenia pyriformis Cambess (Myrtaceae), conhecida popularmente como uvaia. Em seus frutos são encontrados compostos fenólicos com ação antioxidante e nas folhas foram detectados altos teores de flavonoides e taninos hidrolisados que se mostraram inibidor da protease de 2019 - nCoV e SARS-CoV. Neste s...
Antivirales/farmacología, Compuestos Fenólicos, Flavonoides/farmacología, Quercetina/farmacología, Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo/química, Quempferoles/farmacología, Taninos Hidrolizables/farmacología, Cromatografía Líquida de Alta Presión/métodos, Hojas de la Planta/química, Eugenia/química
Fulltext

Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model

Hussain, Zulfia; Khan, Junaid Ali; Arshad, Muhammad Imran; Muhammad, Faqir; Abbas, Rao Zahid.
Bol. latinoam. Caribe plantas med. aromát; 20 (4), 2021
This study was aimed to explore the comparative efficacy of cinnamon bark extract, cinnamaldehyde and kaempferol against acetaminophen (APAP)-induced oxidative stress. Cinnamon bark extract, cinnamaldehyde and kaempferol were utilized or in-vivo analysis. From the results of in-vitro screening tests, ...
Cinnamomum zeylanicum/química, Acroleína/análogos & derivados, Acroleína/química, Quempferoles/química, Antioxidantes/administración & dosificación, Fitoquímicos, Estrés Oxidativo/efectos de los fármacos, Acetaminofén/toxicidad, Modelos Animales de Enfermedad, Extractos Vegetales/administración & dosificación, Ratones Endogámicos BALB C, Hígado/efectos de los fármacos, Cromatografía Líquida de Alta Presión, Riñón/efectos de los fármacos, Hígado/patología, Riñón/patología
Fulltext

Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target

Argüello-García, Raúl; Calzada, Fernando; García-Hernández, Normand; Chávez-Munguía, Bibiana; Velázquez-Domínguez, José Antonio.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Kaempferol (KPF) is a flavonoid with antiparasitic activity including experimental giardiasis which mechanism of action is unknown. OBJECTIVE To analyse the cytotoxic effects of KPF on Giardia duodenalis trophozoites and to identify a likely parasite target of this compound. METHODS We use...
Biología Computacional, Giardia lamblia/efectos de los fármacos, Giardiasis, Quempferoles, Trofozoítos
Fulltext

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis

Zhang, Fan; Ma, Cuimei.
Braz. j. med. biol. res; 52 (2), 2019
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as...
Apoptosis/efectos de los fármacos, Autofagia/efectos de los fármacos, Línea Celular Tumoral, Proliferación Celular/efectos de los fármacos, Quempferoles/farmacología, Neoplasias Gástricas/patología
Fulltext

Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment

Xu, XH; Zhao, C; Peng, Q; Xie, P; Liu, QH.
Braz. j. med. biol. res; 50 (3), 2017
Diabetic retinopathy (DR) is one of the common and specific microvascular complications of diabetes. This study aimed to investigate the anti-angiogenic effect of kaempferol and explore its underlying molecular mechanisms. The mRNA expression level of vascular endothelial growth factor (VEGF) and placent...
Movimiento Celular, Proliferación Celular, Retinopatía Diabética/metabolismo, Retinopatía Diabética/patología, Células Endoteliales/efectos de los fármacos, Ensayo de Inmunoadsorción Enzimática, Inmunohistoquímica, Quempferoles/farmacología, Factor de Crecimiento Placentario/antagonistas & inhibidores, Retina/patología, Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores
Fulltext