LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effects of Chitosan Nanoparticles with Long Synthetic siRNAs Targeting VEGF in Triple-Negative Breast Cancer Cells

Cömez, Birnur; Akbuğa, Jülide.

Braz. J. Pharm. Sci. (Online); 59 (), 2023

Abstract Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, therefore were investigated as cancer therapeutics. In this study, we investig...

Nanopartículas/clasificación, Quitosano/efectos adversos, Factor A de Crecimiento Endotelial Vascular/análisis, d0158700, d0346220, Metástasis de la Neoplasia/diagnóstico, Neoplasias de la Mama Triple Negativas/patología, ARN Interferente Pequeño/farmacología

Fulltext

Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes

Şalva, Emine; Alan, Saadet; Karakoyun, Berna; Çakalağaoğlu, Fulya; Özbaş, Suna; Akbuğa, Jülide.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro prolif...

Usos Terapéuticos, Cicatrización de Heridas, Quitosano/efectos adversos, Factor Estimulante de Colonias de Macrófagos/farmacología, Heridas y Lesiones/inducido químicamente, Proliferación Celular, Terapéutica, Técnicas In Vitro/métodos

Fulltext

Behaviour of diferent types of chitosan membranes implanted in horses

Rollim, Vinícius M; Reginato, Gustavo M; Fernandes, Letícia M; Arantes, Julia A; Rigo, Eliana C. S; Vercik, Luci C. O; Freitas, Silvio H; Dória, Renata G. S.

Pesqui. vet. bras; 39 (10), 2019

Chitosan has been successfully used as a biomaterial with several purposes in many species. In this study, chitosan membranes were produced with six different types of materials, and their behavior were evaluated upon implantation in the subcutaneous tissue of the flank of twelve healthy horses. We asses...

Quitosano/uso terapéutico, Caballos, Quitosano/efectos adversos, Cicatrización de Heridas, Implantes de Medicamentos

Fulltext

Prospecção quantitativa e qualitativa de uma nova fonte renovável de quitosana

Bezerra, Adriana Maia.

A quitosana é um biopolímero funcional com grande potencial de desenvolvimento, podendo gerar diferentes tipos de materiais com variadas funções. Conforme modificações na sua estrutura, a quitosana tem encontrado aplicações nas mais diversas áreas, possuindo um grande leque de aplicações. Apes...

Quitosano/efectos adversos, Biopolímeros, Tecnología Farmacéutica/clasificación, Cucarachas/fisiología, Minería de Datos/clasificación

Fulltext