We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred to as PNTPGS and PNPol, were prepared using nanoprecipitation. They were c...
Abstract Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with the aim of enhancing solubility and in vitro release ...
Abstract Natural products are considered an important source of the therapeutic arsenal currently available. Among these alternatives are the seeds of Ambrosia peruviana (altamisa), whose extract has shown an anti-inflammatory effect. The main objective of this work was to perform a preformulation study ...
O objetivo deste trabalho foi preparar e caracterizar nanocarreadores via auto-organização a partir da pectina de citros e lisozima para o encapsulamento da β-lactose. Foram estudadas três condições de interação entre os biopolímeros variando a razão molar pectina/lisozima (3:1, 2:1, 1:1, 1:2 e...
Abstract To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@R...
Curcumina/análisis,
Citrus sinensis/clasificación,
Concentración de Iones de Hidrógeno,
Color,
Difracción de Rayos X/instrumentación,
Espectroscopía Infrarroja por Transformada de Fourier,
Evaporación/clasificación,
Métodos,
Polímeros,
Solventes/administración & dosificación,
Técnicas In Vitro/métodos,
Rastreo Diferencial de Calorimetría/métodos
Ribeiro, Priscilla Tobias;
Pedrosa, Tatiana do Nascimento;
Chaves, Francisco Celio Maia;
José Quintans-Júnior, Lucindo;
Araújo, Adriano Antunes de Souza;
Vasconcellos, Marne Carvalho de;
Maria-Engler, Silvya Stuchi;
Silva, Cláudia Cândida;
Silva, Felipe Moura Araújo da;
Koolen, Héctor Henrique Ferreira;
Lima, Emerson Silva;
Lima, Ádley Antonini Neves de.
Abstract Passiflora nitida Kunth, an Amazonian Passiflora species, is little studied, although the specie’s high biological potential. Herein the plant’s pharmacognostic characterization, extract production, antioxidant potential evaluation, and application of this extract in cosmetic products is rep...
Passiflora/clasificación,
Extractos Vegetales/análisis,
Hojas de la Planta/efectos adversos,
Monofenol Monooxigenasa/antagonistas & inhibidores,
Cosméticos/clasificación,
Antioxidantes/efectos adversos,
Compuestos Fenólicos,
Melaninas,
Rayos X/efectos adversos,
Termogravimetría/métodos,
Rastreo Diferencial de Calorimetría/métodos
Abstract The study is aimed to develop a monolithic controlled matrix transdermal patches containing Metoclopramide as a model drug by solvent casting method. Eudragit L100, Polyvinylpyrrolidone K-30, and Methylcellulose were used in different ratios and Polyethylene glycol 400 added as a plasticizer. Re...
Diante das exigências crescentes das agências regulatórias do mundo todo quanto à redução/eliminação de ácidos graxos trans nos alimentos industrializados, bem como da conscientização do consumidor sobre a relação entre alimentação e saúde, o desenvolvimento de alternativas mais saudávei...
A baixa solubilidade aquosa dos insumos farmacêuticos ativos (IFA) é um grande desafio no desenvolvimento de formulações farmacêuticas, pois pode resultar em biodisponibilidade insuficiente e variável. Diversas estratégias de modificação do estado sólido dos compostos ativos, têm sido proposta...
Poloxámero/análogos & derivados,
Insumos Farmacéuticos,
Análisis Espectral/instrumentación,
Análisis de Fourier,
ADN Polimerasa Dirigida por ARN/efectos adversos,
Derivados de la Hipromelosa/metabolismo,
Disolución,
Espectroscopía Infrarroja por Transformada de Fourier,
Preparaciones Farmacéuticas/administración & dosificación,
Terapia Antirretroviral Altamente Activa/instrumentación,
Rastreo Diferencial de Calorimetría/métodos
Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate mucoadhesive buccal tablet using Mefenamic acid and compatible excipients, and to evaluate the product using quality control tests and ...
