SUMMARY: Aging is an inevitable biological process that affects the function of all organs, including the adrenal gland, which is essential for producing steroid hormones that regulate metabolism, stress response, and immune activation. Understanding how aging affects the morphology of this gland is cruc...
SUMMARY: Underage drinking has become a major public concern having a negative impact on the growth and development of the skeleton. Peak bone mass is attained during adolescence hence the aim of the study was to investigate the effect of acute binge alcohol consumption on trabecular morphometry and tens...
Consumo Excesivo de Bebidas Alcohólicas,
Mandíbula/efectos de los fármacos,
Resistencia a la Tracción,
Ratas Sprague-Dawley,
Hueso Esponjoso/efectos de los fármacos,
Factores Sexuales,
Nivel de Alcohol en Sangre,
Fenómenos Biomecánicos,
Densidad Ósea,
Modelos Animales de Enfermedad,
Etanol/toxicidad
SUMMARY: Binge drinking in adolescents has a negative effect on the developing skeleton and the attainment of peak bone mass. Our study aimed to examine the effect of binge drinking on the growth and functional integrity of the adolescent Sprague Dawley rat mandible and to determine if a dosage of 1.5 g/...
SUMMARY: The study explores the relationship between chronic exposure to fine particulate matter (PM2.5), sourced from wood smoke, and the histological structure and endocrine function of the uterus in nulliparous adult rats. It assesses potential structural changes in the uterus that could impact reprod...
SUMMARY: Systemic inflammatory response syndrome (SIRS) is a potentially fatal reaction to various forms of tissue damage and infections that cause damage to various organs. Furthermore, the brain is damaged earlier than other organs, resulting in diffuse brain dysfunction. The central clinical symptom o...
SUMMARY: Excessive alcohol consumption adversely affects bone metabolism, thus resulting in reduced bone length, density, and strength. Moreover, these deficits in bone density and strength are likely to increase the risk of fragility fractures and the early onset of osteoporosis. While excessive alcohol...
SUMMARY: We evaluated the role and mechanism of acteoside in the regulation of memory impairment induced by chronic unpredictable mild stress (CUMS). CUMS was used to induce depression in rats and the successful establishment of CUMS model were verified by forced swimming test and sucrose preference test...
Estrés Psicológico/complicaciones,
Trastornos de la Memoria/tratamiento farmacológico,
Glucósidos/administración & dosificación,
Glucósidos/uso terapéutico,
Polifenoles/administración & dosificación,
Polifenoles/uso terapéutico,
Reconocimiento en Psicología/efectos de los fármacos,
Plasticidad Neuronal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Depresión/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Escala de Evaluación de la Conducta,
Neuronas,
Técnica del Anticuerpo Fluorescente,
Western Blotting,
Aprendizaje por Laberinto,
Inhibidores mTOR
Bashir, Salah O;
Morsy, Mohamed D;
Mohammed, Muataz E;
Abbas, Amr M;
Badi, Rehab M;
Osman, Osama M;
Dawood, Amal F;
Saeed, Amal M;
Eid, Refaat A;
Sabir, Deema K.
SUMMARY: This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, and oxidative stress in a rat model of diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, norm...
Acacia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Nefropatías Diabéticas/tratamiento farmacológico,
ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos,
ATPasa Intercambiadora de Sodio-Potasio/genética,
Estrés Oxidativo,
Control Glucémico,
Insulina/administración & dosificación,
Quimioterapia Combinada,
Expresión Génica,
Malondialdehído,
Superóxido Dismutasa,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Riñón/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Hemoglobina Glucada/análisis,
d0123330
Chronic stress (CS) can contribute to dysfunction in several organs including liver and kidney. This study was performed to investigate the changes in serum biochemistry, histological structure, as well as in localization of tyrosine phosphorylated proteins (TyrPho) and Heat shock protein 70 (Hsp-70) in ...
SUMMARY: The R-spondin protein family is a group of proteins that enhance Wnt/b-catenin signaling and have pleiotropic functions in stem cell growth and development. In the literature reviews, there is no histomorphological study showing the localization and distribution of R-spondins in different hypoth...
