ABSTRACT Purpose: We assessed the efficacy and safety of a single injection of three bulking agents over the short- and long-term follow-ups in rabbits. Dermal and preputial matrices were compared with Deflux (DxHA) injection. Material and methods: Twenty-four rabbits were divided into three groups. Gr...
ABSTRACT Background: Cancer gene therapy using a nonviral vector is expected to be repeatable, safe, and inexpensive, and to have long-term effectiveness. Gene therapy using the E3 and C1 (E3C1) domain of developmental endothelial locus-1 (Del1) has been shown to improve prognosis in a mouse transplante...
Secuencias de Aminoácidos,
Proteínas de Unión al Calcio/genética,
Proteínas de Unión al Calcio/uso terapéutico,
Carcinoma de Células Escamosas/irrigación sanguínea,
Carcinoma de Células Escamosas/terapia,
Moléculas de Adhesión Celular/genética,
Moléculas de Adhesión Celular/uso terapéutico,
Dominio Discoidina/genética,
Factor de Crecimiento Epidérmico/genética,
Factor de Crecimiento Epidérmico/uso terapéutico,
Terapia Genética,
Ratones Desnudos,
Trasplante de Neoplasias,
Neovascularización Patológica/terapia,
Células Tumorales Cultivadas
Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels o...
Epidermal growth factor receptor (EGFR) signaling and components of the fibrinolytic system, including urokinase-type plasminogen activator (uPA) and thrombomodulin (TM), have been implicated in tumor progression. In the present study, we employed cBioPortal platform (http://www.cbioportal.org/), cancer ...
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ect...
This work aimed to research the function of MARVEL domain-containing protein 1 (MARVELD1) in glioma as well as its functioning mode. Bioinformatics analysis was utilized to assess the MARVELD1 expression in glioma tissues and its relationship with grade and prognosis, based on The Cancer Genome Atlas (TC...
Neoplasias Encefálicas,
Línea Celular Tumoral,
Movimiento Celular,
Proliferación Celular,
Regulación Neoplásica de la Expresión Génica,
Glioma,
Proteínas con Dominio MARVEL,
Proteínas de la Membrana,
Ratones Desnudos,
Proteínas Asociadas a Microtúbulos,
Fenotipo,
Transducción de Señal,
Regulación hacia Arriba
The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa cells were divided into six groups: control group, NC group, SULF2 s...
Apoptosis,
Estudios de Casos y Controles,
Línea Celular Tumoral,
Regulación Neoplásica de la Expresión Génica,
Células HeLa,
Inmunohistoquímica,
Sistema de Señalización de MAP Quinasas/genética,
Sistema de Señalización de MAP Quinasas/fisiología,
Ratones Desnudos,
Estadificación de Neoplasias,
Proteínas Proto-Oncogénicas c-akt/genética,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Sulfatasas/genética,
Sulfatasas/metabolismo,
Neoplasias del Cuello Uterino/metabolismo
RU486 (mifepristone), a glucocorticoid and progesterone receptor antagonist, has been reported to exert antiproliferative effects on tumor cells. Experiments were performed to analyze the effects of RU486 on the proliferation of the human neuroblastoma, both in vitro and in vivo, using the human neurobla...
Nogueira, Maria Renata Sales;
Amôr, Nádia Ghinelli;
Michellin, Letícia Baccaro;
Cury Filho, Milton;
Rosa, Patrícia Sammarco;
Latini, Ana Carla Pereira;
Rodrigues, Luciana Silva;
Lemes, Robertha Mariana Rodrigues;
Lara, Flavio Alves;
Pessolani, Maria Cristina Vidal.
BACKGROUND Although Mycobacterium leprae (ML) is well characterised as the causative agent of leprosy, the pathophysiological mechanisms underlying peripheral nerve damage still need further understanding. In vitro and in vivo studies have yielded insights into molecular mechanisms of ML interaction wit...
Abstract: Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exem...
Ascomicetos,
Recuento de Células Sanguíneas,
Cromoblastomicosis/inmunología,
Cromoblastomicosis/patología,
Enfermedad Crónica,
Dermatomicosis/inmunología,
Dermatomicosis/patología,
Modelos Animales de Enfermedad,
Inmunocompetencia,
Inflamación/inmunología,
Inflamación/microbiología,
Inflamación/patología,
Ratones Endogámicos BALB C,
Ratones Endogámicos C57BL,
Ratones Desnudos,
Ratones SCID,
Neutrófilos,
Especificidad de la Especie,
Factores de Tiempo
