Abstract Purpose To investigate the effects of grape seed proanthocyanidin B2 (GSPB2) preconditioning on oxidative stress and apoptosis of renal tubular epithelial cells in mice after renal ischemia-reperfusion (RIR). Methods Forty male ICR mice were randomly divided into 4 groups: Group A: mice were t...
Acute effect of purified mimosine (MiMo) extracted from Leucaena leucocephala on testicular histopathology has been documented with seminal vesicle (SV) atrophy. Since protein phosphorylation and seminal secretions play important roles in sperm physiology, this study aimed to study the alteration of subs...
Vesículas Seminales/efectos de los fármacos,
Mimosina/administración & dosificación,
Mimosina/farmacología,
Ratones Endogámicos ICR,
Tamaño de los Órganos,
Vesículas Seminales/patología,
Electroforesis en Gel de Poliacrilamida,
Western Blotting,
Fosfoproteínas/efectos de los fármacos,
Fosfoproteínas/metabolismo,
Fosfotirosina,
Fosforilación,
Tirosina/análogos & derivados
Abstract Introduction: Parkinson's disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B. ...
Antiparkinsonianos/uso terapéutico,
Inhibidores de la Monoaminooxidasa/uso terapéutico,
Enfermedad de Parkinson Secundaria/tratamiento farmacológico,
Antiparkinsonianos/administración & dosificación,
Carbidopa/administración & dosificación,
Catalepsia/inducido químicamente,
Cumarinas,
Modelos Animales de Enfermedad,
Combinación de Medicamentos,
Evaluación Preclínica de Medicamentos,
Haloperidol,
Levodopa/administración & dosificación,
Locomoción/efectos de los fármacos,
Ratones Endogámicos ICR,
Inhibidores de la Monoaminooxidasa/administración & dosificación,
Enfermedad de Parkinson Secundaria/inducido químicamente,
Reserpina/administración & dosificación
This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 mg/KgBW, respec...
Abstract Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was administrated one hour after the final intr...
Antineoplásicos/efectos adversos,
Antioxidantes/farmacología,
Aspartato Aminotransferasas/metabolismo,
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Cisplatino/efectos adversos,
Quercetina/análogos & derivados,
Alanina Transaminasa/metabolismo,
Antioxidantes/uso terapéutico,
Catalasa/análisis,
Enfermedad Hepática Inducida por Sustancias y Drogas/patología,
Cisplatino/antagonistas & inhibidores,
Glutatión/análisis,
Glutatión Peroxidasa/análisis,
Glutatión Transferasa/análisis,
Peroxidación de Lípido,
Hígado/efectos de los fármacos,
Hígado/enzimología,
Hígado/patología,
Malondialdehído/análisis,
Ratones Endogámicos ICR,
Estrés Oxidativo/efectos de los fármacos,
Quercetina/farmacología,
Quercetina/uso terapéutico,
Distribución Aleatoria,
Valores de Referencia,
Reproducibilidad de los Resultados
The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male m...
Momordica/química,
Extractos Vegetales/administración & dosificación,
Enfermedades Testiculares/tratamiento farmacológico,
Hiperglucemia/tratamiento farmacológico,
Diabetes Mellitus Experimental,
Testículo/efectos de los fármacos,
Fosforilación/efectos de los fármacos,
Tirosina,
Espermatozoides/efectos de los fármacos,
Antioxidantes/administración & dosificación,
Hipoglucemiantes/administración & dosificación,
Western Blotting,
Ratones Endogámicos ICR,
Recuento de Espermatozoides,
Antioxidantes/química,
Fenoles/análisis,
Flavonoides/análisis
Subcutaneous mass was found in ICR mouse during daily health observation in the breeding colony of the National Laboratory Animal Center, Mahidol University, Thailand. The animal was subsequently culled and humanely sacrificed due to the institutional preventive medicine policy. Microbiological and histo...
Diazepam (DZ) is a benzodiazepine that belongs to the group of minor tranquilizers with myo-relaxing and anticonvulsant properties. DZ and its metabolites cross the placental barrier in human, monkey, hamster, and mouse, and accumulate in the placenta. Our aim was to investigate, through histological tec...
BACKGROUND: Despite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the effect of the total extract and pr...
Antiinflamatorios/farmacología,
Apocynaceae/química,
Edema/tratamiento farmacológico,
Macrófagos/efectos de los fármacos,
Extractos Vegetales/uso terapéutico,
Línea Celular Tumoral/efectos de los fármacos,
Citotoxinas/farmacología,
Dinoprostona/análisis,
Inflamación/tratamiento farmacológico,
Óxido Nítrico/análisis,
Oxitócicos/análisis,
Peroxidasa/antagonistas & inhibidores,
Hojas de la Planta/química,
Ratones Endogámicos ICR
