Sepúlveda, Carlos;
Rodríguez, Juan Manuel;
Monsalves-Álvarez, Matías;
Donoso-Barraza, Camila;
Pino-de la Fuente, Francisco;
Matías, Isabelle;
Leste-Lasserre, Thierry;
Zizzari, Philippe;
Morselli, Eugenia;
Cota, Daniela;
Llanos, Miguel;
Troncoso, Rodrigo.
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise, autophagy is involved in several cellular processes. It is required for the normal development...
Skeletal muscle is an important metabolic tissue in glucose uptake and thus in glycemic homeostasis. Evidence suggests that phenolic compounds may exert beneficial health effects against metabolic disorders associated to obesity including its state of peripheral insulin resistance. The objective of this ...
Resumo Fundamentos A L-carnitina (LC) tem muitos efeitos benéficos em animais diabéticos e humanos, mas seu efeito regulatório sobre a quemerina como uma citocina inflamatória e seu receptor no estado diabético são desconhecidos. Objetivos O presente estudo teve como objetivo investigar o efeit...
Jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian native fruit belonging to the Myrtaceae family. Previously it was demonstrated that phenolicrich extracts from jaboticaba (PEJ) possess health-beneficial properties in dietinduced obesity; however, whether PEJ modulates the obesity-associated int...
Compuestos Fenólicos,
Myrtaceae/clasificación,
Frutas/metabolismo,
Obesidad/tratamiento farmacológico,
Antiinflamatorios/efectos adversos,
Aumento de Peso,
Ratones Obesos/clasificación,
Dieta,
Factor de Necrosis Tumoral alfa/efectos adversos,
Ingestión de Alimentos,
Resistencia a la Insulina
ABSTRACT Objective To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet. Methods Male C57Bl6 mice aged 9 weeks were allocated to one of two groups - Control and Obese, and fed a standard or hig...
Tejido Adiposo/patología,
Fármacos Antiobesidad/farmacología,
Fármacos Antiobesidad/uso terapéutico,
Peso Corporal/efectos de los fármacos,
Colesterol/análisis,
Dieta Alta en Grasa/efectos adversos,
Ingestión de Alimentos/efectos de los fármacos,
Hígado Graso/patología,
Tránsito Gastrointestinal/efectos de los fármacos,
Prueba de Tolerancia a la Glucosa,
Hígado/metabolismo,
Ratones Endogámicos C57BL,
Ratones Obesos,
Obesidad/tratamiento farmacológico,
Obesidad/etiología,
Obesidad/fisiopatología,
Reproducibilidad de los Resultados,
Sericinas/farmacología,
Factores de Tiempo,
Resultado del Tratamiento,
Triglicéridos/análisis,
Aumento de Peso/efectos de los fármacos,
Sericinas/uso terapéutico
ABSTRACT Objective To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity. Methods Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight ...
Tejido Adiposo Blanco/fisiopatología,
Adiposidad/fisiología,
Glucemia/análisis,
Peso Corporal/fisiología,
Dieta Alta en Grasa,
Ensayo de Inmunoadsorción Enzimática,
Hipertrofia/fisiopatología,
Inflamación/fisiopatología,
Resistencia a la Insulina/fisiología,
Ratones,
Ratones Obesos,
Ejercicios de Estiramiento Muscular/métodos,
Obesidad/fisiopatología,
Condicionamiento Físico Animal/fisiología,
Reproducibilidad de los Resultados,
Entrenamiento de Fuerza/métodos,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/análisis
Obese mice (C57BL/6J-ob/ob) do not express leptin and develops hyperphagia, decreased energy expenditure, obesity, hyperglycemia, hyperinsulinemia, hypothermia, and infertility. Obesity causes reproductive dysfunction with negative impacts on prostatic structure and fertility. We aimed to compare the str...
ResumenAntecedentes:la albahaca (Ocium basilicum) es una hierba perteneciente a la familia laminaceae, caracterizada por sus bondades medicinales. Se ha referido su uso en la terapéutica del cáncer, vitíiigo, hipercolesterolemia y la diabetes mellitus.Objetivo:evaluar el efecto hipoglicemiante del ext...
