Introdução: A periodontite é um importante problema de saúde pública. Embora o princípio da terapia da periodontite esteja focado principalmente na remoção do biofilme dental e dos fatores associados, sua fisiopatologia registra diferentes eventos moleculares e inflamatórios relacionados ao sist...
Sepúlveda, Carlos;
Rodríguez, Juan Manuel;
Monsalves-Álvarez, Matías;
Donoso-Barraza, Camila;
Pino-de la Fuente, Francisco;
Matías, Isabelle;
Leste-Lasserre, Thierry;
Zizzari, Philippe;
Morselli, Eugenia;
Cota, Daniela;
Llanos, Miguel;
Troncoso, Rodrigo.
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise, autophagy is involved in several cellular processes. It is required for the normal development...
Abstract Metabolic syndrome (MetS), an epidemic defined as a group of interconnected physiological, biochemistry, clinical, and metabolic factors, directly increases the risk of cardiovascular disease, atherosclerosis, type 2 diabetes, and death. MetS therapy includes diet, physical exercise, and a poly-...
Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic ef...
Cannabidiol/aislamiento & purificación,
Cannabidiol/uso terapéutico,
Cannabinoides/farmacología,
Cannabis,
Dronabinol/aislamiento & purificación,
Dronabinol/farmacología,
Endocannabinoides/metabolismo,
Marihuana Medicinal/uso terapéutico,
Receptor Cannabinoide CB1/metabolismo,
Receptor Cannabinoide CB2/metabolismo,
Porcinos,
Canales Catiónicos TRPV/metabolismo
Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic ...
Cannabinoid type 1 receptor (CB1R) inhibition tends to be one of the promising strategies for the treatment of obesity and other related metabolic disorders. Although CB1R inhibition may cause adverse psychiatric effects including depression and anxiety, the investigation of the role of peripheral CB1R o...
Glucemia/efectos de los fármacos,
Peso Corporal/efectos de los fármacos,
Canales de Calcio/efectos de los fármacos,
Canales de Calcio/metabolismo,
Canales de Calcio Tipo L/efectos de los fármacos,
Canales de Calcio Tipo L/metabolismo,
Antagonistas de Receptores de Cannabinoides/farmacología,
Dieta Alta en Grasa/efectos adversos,
Intolerancia a la Glucosa/etiología,
Resistencia a la Insulina,
Ratones Endogámicos C57BL,
Modelos Animales,
Músculo Esquelético/efectos de los fármacos,
Músculo Esquelético/metabolismo,
Obesidad/etiología,
Piperidinas/farmacología,
Pirazoles/farmacología,
Receptor Cannabinoide CB1/antagonistas & inhibidores,
Receptor Cannabinoide CB1/fisiología
Background: Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible invol...
RESUMO Objetivo: Investigar os efeitos da administração de canabidiol em um modelo de isquemia/reperfusão renal em animais. Métodos: Foi induzida uma lesão renal, por meio de 45 minutos de isquemia renal seguida por reperfusão. Administrou-se canabidiol (5mg/kg) imediatamente após a reperfusão. R...
Cannabidiol/farmacología,
Modelos Animales de Enfermedad,
Inflamación/tratamiento farmacológico,
Inflamación/patología,
Interleucina-1/metabolismo,
Enfermedades Renales/tratamiento farmacológico,
Enfermedades Renales/patología,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Receptor Cannabinoide CB1/metabolismo,
Receptor Cannabinoide CB2/metabolismo,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/patología,
Factor de Necrosis Tumoral alfa/metabolismo
In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In subm...
Tics are the hallmarks of a Tourette syndrome (TS). Dopamine receptor antagonists are the approved treatment, although neuroleptic treatment is often unsatisfactory due to side effects. Therefore, there is expanding interest in new therapeutic strategies. From anecdotal reports it has been suggested that...
