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Regulation of Notch1 and Foxp1 by MiR-34a in psoriasis vulgaris

Wang, Huiqin; Zhang, Xiaoling; Bu, Juan; Wu, Weidong.
Int. j. morphol; 40 (3), 2022
SUMMARY: This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in the development of psoriasis vulgaris. RT-PCR was used to compare the levels of miR-34a in the skin lesions of 20 patients with psoriasis vulgaris and 20 normal skin tissues. Immunohistochemistry was used to detect the...
Psoriasis/genética, Psoriasis/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Receptor Notch1/genética, Receptor Notch1/metabolismo, Factores de Transcripción Forkhead/genética, Factores de Transcripción Forkhead/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Inmunohistoquímica, Transfección, Western Blotting
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Combinación de bardoxolona y DMF Mejora la isquemia cerebral/reperfusión Lesión en ratas macho
Combination of Bardoxolone and DMF Ameliorates Cerebral Ischemia / Reperfusion Injury in Male Rats

Abbas Al-Huseini, Laith M; Al-Mudhaffer, Rihab H; Abosaooda, Munther; Hassan, Saif M; Hadi, Najah R.
Prensa méd. argent; 106 (3), 2020
Background: Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury. The present study aimed to investigate the effect of Berberine on cerebral I/R inju...
Isquemia Encefálica/terapia, Daño por Reperfusión/terapia, Ratas Wistar, Berberina/uso terapéutico, Receptor Notch1, Proteína Jagged-1, Caspasa 1
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Mutaciones del gen NOTCH1 en la leucemia linfocítica crónica

Galvano, Camila; Dos Santos, Patricia; Stanganelli, Carmen; Slavutsky, Irma.
Salud(i)ciencia (Impresa); 23 (4), 2019
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease hasa highly variable clinical course, ranging from very indolent cases to patients with aggressive and rapidlyprogressing outcome. Genetic studies are useful tools in analyzing this pathology, and have been i...
Leucemia Linfocítica Crónica de Células B, Receptor Notch1, Mutación/genética, Citogenética
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HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression

Cheng, Hao; Zhu, Hao; Cao, Meng; Lu, Chenglin; Bao, Shanhua; Pan, Yiming.
Braz. j. med. biol. res; 52 (1), 2019
Pancreatic cancer is well known to be the most deadly malignancy with the worst survival rate of all cancers. High temperature requirement factor A1 (HtrA1) plays an important role in cancer cell proliferation, migration, apoptosis, and differentiation. This study aimed to explore the function of HtrA1 i...
Apoptosis, Diferenciación Celular, Línea Celular Tumoral, Proliferación Celular, Regulación Neoplásica de la Expresión Génica/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/metabolismo, Neoplasias Pancreáticas/genética, Neoplasias Pancreáticas/metabolismo, Neoplasias Pancreáticas/patología, Receptor Notch1/genética, Receptor Notch1/metabolismo, Transducción de Señal, Regulación hacia Arriba
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Caracterização da inter-relação entre as vias de sinalização Notch e TLR na paracoccidioidomicose experimental

Romera, Lavínia Maria Dal'Mas.
A paracoccidioidomicose é uma micose sistêmica de natureza profunda que afeta preferencialmente o tecido pulmonar podendo disseminar via linfo-hematogênica para outros órgãos e tecidos, sendo causada principalmente pelo Paracoccidioides brasiliensis, fungo que apresenta dimorfismo térmico. O sistem...
34921, Receptor Toll-Like 4/clasificación, Micosis/prevención & control, Paracoccidioidomicosis/complicaciones, Macrófagos, Paracoccidioides, Receptor Notch1/clasificación, Secretasas de la Proteína Precursora del Amiloide/administración & dosificación, 34921
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