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Regulation of Notch1 and Foxp1 by MiR-34a in psoriasis vulgaris

Wang, Huiqin; Zhang, Xiaoling; Bu, Juan; Wu, Weidong.
Int. j. morphol; 40 (3), 2022
SUMMARY: This study is to investigate the regulation of Notch1 and Foxp1 by miR-34a in the development of psoriasis vulgaris. RT-PCR was used to compare the levels of miR-34a in the skin lesions of 20 patients with psoriasis vulgaris and 20 normal skin tissues. Immunohistochemistry was used to detect the...
Psoriasis/genética, Psoriasis/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Receptor Notch1/genética, Receptor Notch1/metabolismo, Factores de Transcripción Forkhead/genética, Factores de Transcripción Forkhead/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Inmunohistoquímica, Transfección, Western Blotting
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HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression

Cheng, Hao; Zhu, Hao; Cao, Meng; Lu, Chenglin; Bao, Shanhua; Pan, Yiming.
Braz. j. med. biol. res; 52 (1), 2019
Pancreatic cancer is well known to be the most deadly malignancy with the worst survival rate of all cancers. High temperature requirement factor A1 (HtrA1) plays an important role in cancer cell proliferation, migration, apoptosis, and differentiation. This study aimed to explore the function of HtrA1 i...
Apoptosis, Diferenciación Celular, Línea Celular Tumoral, Proliferación Celular, Regulación Neoplásica de la Expresión Génica/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/metabolismo, Neoplasias Pancreáticas/genética, Neoplasias Pancreáticas/metabolismo, Neoplasias Pancreáticas/patología, Receptor Notch1/genética, Receptor Notch1/metabolismo, Transducción de Señal, Regulación hacia Arriba
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