LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Fibroblast growth factor receptor 3 gene (FGFR3) mutations in high-grade muscle-invasive urothelial bladder cancer in a Brazilian population: evaluation and prevalence

Monteiro, Camila Ribeiro de Arruda; Korkes, Fernando; Krutman-Zveibil, Deborah; Glina, Sidney.

Einstein (São Paulo, Online); 20 (), 2022

ABSTRACT Objective To understand the feasibility of FGFR3 tests in the Brazilian public health context, and to sample the mutational burden of this receptor in high-grade muscle invasive bladder cancer. Methods A total of 31 patients with high-grade muscle-invasive bladder cancer were included in the...

Brasil, Carcinoma de Células Transicionales/genética, Carcinoma de Células Transicionales/metabolismo, Carcinoma de Células Transicionales/patología, Eosina Amarillenta-(YS), Hematoxilina, Músculos/metabolismo, Músculos/patología, Mutación, Prevalencia, ARN, Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/genética, Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/metabolismo, Neoplasias de la Vejiga Urinaria/genética

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Natural history of 39 patients with Achondroplasia

Ceroni, Jose Ricardo Magliocco; Soares, Diogo Cordeiro de Queiroz; Testai, Larissa de Cássia; Kawahira, Rachel Sayuri Honjo; Yamamoto, Guilherme Lopes; Sugayama, Sofia Mizuho Miura; Oliveira, Luiz Antonio Nunes de; Bertola, Debora Romeo; Kim, Chong Ae.

Clinics; 73 (), 2018

OBJECTIVES: To characterize the natural history of 39 achondroplastic patients diagnosed by clinical, radiological and molecular assessments. METHODS: Observational and retrospective study of 39 patients who were attended at a public tertiary level hospital between 1995 and 2016. RESULTS: Diagnosis was...

Acondroplasia/diagnóstico, Acondroplasia/genética, Acondroplasia/patología, Factores de Edad, Estudios de Seguimiento, Técnicas de Diagnóstico Molecular, Mutación, Radiografía, Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/genética, Estudios Retrospectivos

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Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells

Zang, Chongsen; Liu, Zixuan; Yang, Kunmeng; Li, Rui; Wang, Xinxin; Zhang, Jizhou; Xiao, Yechen.

Electron. j. biotechnol; 28 (), 2017

Background: Gain-of-function of fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies have focused on the potential usage of therapeutic single-chain Fv (ScFv) antibodies against FGFR3. RNA interference (RNAi) has been considered as a promising ...

Anticuerpos de Cadena Única/metabolismo, Anticuerpos de Cadena Única/aislamiento & purificación, Proteínas Recombinantes de Fusión/metabolismo, Protaminas/metabolismo, Escherichia coli/metabolismo, Cuerpos de Inclusión, Citometría de Flujo, Apoptosis, Anticuerpos de Cadena Única/genética, Proteínas Recombinantes de Fusión/genética, Clonación Molecular, ARN Interferente Pequeño, Neoplasias de la Vejiga Urinaria/metabolismo, Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos

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Expression and purification of soluble single-chain Fv against human fibroblast growth factor receptor 3 fused with Sumo tag in Escherichia coli

Liu, Zixuan; Zhang, Jizhou; Fan, Hongqiong; Yin, Ruofeng; Zheng, Zhong; Xu, Qian; Liu, Qing; He, Haiting; Peng, Xiaofan; Wang, XinXin; Li, Xiaokun; Xiao, Yechen.

Electron. j. biotechnol; 18 (4), 2015

Background Overexpression or mutated activation of Fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies focus on the potential usage of therapeutic antibodies against FGFR3. Results In this study, a novel single-chain Fv (ScFv) against FGFR3 wa...

Anticuerpos de Cadena Única/aislamiento & purificación, Anticuerpos de Cadena Única/metabolismo, Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/metabolismo, Solubilidad, Escherichia coli, Western Blotting, Espectrometría de Masas, Proteínas Recombinantes

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