Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis
Arch. endocrinol. metab. (Online); 65 (2), 2021
ABSTRACT Objective: Abnormalities involving the TGFB1 gene and its receptors are common in several types of cancer and often related to tumor progression. We investigated the role of single nucleotide polymorphisms (SNP) in the susceptibility to cancer, their impact on its features, as well as the role ...
Polimorfismo de Nucleótido Simple, ARN Mensajero/genética, Receptor Tipo I de Factor de Crecimiento Transformador beta/genética, Receptor Tipo II de Factor de Crecimiento Transformador beta/genética, Neoplasias de la Tiroides, Nódulo Tiroideo/genética, Factor de Crecimiento Transformador beta1/genética, Microambiente Tumoral