A família dos receptores de cininas compreende dois subtipos, sendo o B1R aquele
em tem como um de seus agonistas fisiológicos a des-Arg9
-BK (DBK). O receptor B1
tem baixa expressão ou está até mesmo ausente em condições fisiológicas normais,
podendo ser induzido por vários estímulos, como o p...
SUMMARY: The aim of this study is to reveal the gonadoprotective effects of myricetin (MYC), which has many biological properties, on cisplatin (CP)-induced testicular damage in rats. For this purpose, 40 male Wistar albino rats were divided into 4 groups as Control (group given no treatment), MYC (group...
Flavonoides/administración & dosificación,
Flavonoides/farmacología,
Testículo/lesiones,
Testículo/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Respuesta al Choque Térmico,
Inflamación,
Ratas Wistar,
Receptor Toll-Like 4,
FN-kappa B,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ
Taha, Medhat;
Ibrahim, Mohie Mahmoud;
Elazab, Sara T;
Badawy, Alaa. M;
Abdelsalam, Ramy A;
Saati, Abdullah A;
Qusty, Naeem F;
Babateen, Omar;
Abdelbagi, Omer;
Hendawy, M.
SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...
Antraquinonas/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Daño por Reperfusión/tratamiento farmacológico,
Antraquinonas/inmunología,
Células Dendríticas/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Enfermedades Renales/tratamiento farmacológico,
Daño por Reperfusión/inmunología,
Enfermedades Renales/inmunología,
Inyecciones Intraperitoneales,
FN-kappa B/metabolismo,
Receptor Toll-Like 4/metabolismo,
Transducción de Señal,
Estrés Oxidativo,
Inflamación,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Interleucina-1beta/metabolismo,
Citometría de Flujo,
d0201690,
d0200110
The current study was conducted to determine the neuroprotective role and mechanism of action of Linalool (LIN) in SCI. The SCI in Sprague-Dawley (SD) rats was induced by weight-drop contusion model. Results of the suggested that LIN showed improvement in the locomo...
Monoterpenos Acíclicos/administración & dosificación,
Monoterpenos Acíclicos/farmacología,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Ratas Sprague-Dawley,
Estrés Oxidativo/efectos de los fármacos,
Inflamación,
Western Blotting,
FN-kappa B/antagonistas & inhibidores,
Receptor Toll-Like 4/antagonistas & inhibidores,
Transducción de Señal/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática
Abstract Background Morphine is an analgesic agent used for cancer pain management. There have been recent concerns that the immunosuppressant properties of morphine can also promote cancer metastasis. Morphine is an agonist for toll like receptor 4 (TLR4) that has a dual role in cancer development. The...
Purpose:
To analyze the effect and mechanism of dexmedetomidine (DEX) analgesia pretreatment on functional chronic visceral pain in rats.
Methods:
Rats were divided into six groups: W1, W2, W3, W4, W5, and W6. The behavioral changes and electrophysiological indexes of rats in each group before and after...
Atualmente, na literatura, existem diversos tipos de dietas alimentares administradas em animais que visam verificar os efeitos em seu metabolismo e em sua saúde sistêmica, com intuito de compreender como essas dietas podem afetar a saúde humana. Sendo assim, é fundamental verificar a relação entre...
d0040320,
d0593050,
d0183840,
d0072490,
Melatonina,
d0172080,
Receptor Toll-Like 4,
d0073330,
Tejido Periapical,
Periodontitis Periapical,
Músculo Esquelético,
Diabetes Mellitus
Alves, Pedro Henrique Rizzi;
Ferron, Artur Junio Togneri;
Costa, Mariane Róvero;
Hasimoto, Fabiana Kurokawa;
Gregolin, Cristina Schmitt;
Garcia, Jéssica Leite;
Campos, Dijon Henrique Salomé de;
Cicogna, Antônio Carlos;
Mattei, Letícia de;
Moreto, Fernando;
Bazan, Silméia Garcia Zanati;
Francisqueti-Ferron, Fabiane Valentini;
Corrêa, Camila Renata.
Resumo Fundamento A obesidade é uma condição inflamatória crônica de baixo grau relacionada a distúrbios cardíacos. No entanto, o mecanismo responsável pela inflamação cardíaca relacionada à obesidade não é claro. O receptor do tipo toll 4 (TLR-4) pertence a um receptor da família das tra...
OBJECTIVES: To investigate the role of miR-139-5p and the TLR4/MyD88/NF-κB signaling pathway in acute lung injury in septic mice. METHOD: A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-...
Neonatal sepsis is an inflammatory system syndrome and a main cause of neonatal mortality. However, there is a lack of ideal biomarkers for early neonatal sepsis diagnosis. The aim of this study was to evaluate the clinical significance of miR-141 in sepsis in neonates, and explore the regulatory effects...
