LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy

Kan, Minchen; Song, Lihong; Zhang, Xueqiang; Zhang, Jing; Fang, Pingping.

Braz. j. med. biol. res; 52 (7), 2019

This study aimed to investigate the association of serum high-mobility group box-1 (HMGB1) and toll-like receptor 4 (TLR4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. One hundred and five epilepsy patients and 100 health...

Anticonvulsivantes/uso terapéutico, Estudios de Casos y Controles, Ensayo de Inmunoadsorción Enzimática, Epilepsia/sangre, Epilepsia/tratamiento farmacológico, Proteína HMGB1/sangre, Valor Predictivo de las Pruebas, Factores de Riesgo, Índice de Severidad de la Enfermedad, Receptor Toll-Like 4/sangre

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Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats

Lou, Zhaohuan; Wang, Junwei; Chen, Yingjun; Xu, Chandi; Chen, Xinyi; Shao, Tiejuan; Zhang, Kena; Pan, Hongying.

Braz. j. med. biol. res; 52 (6), 2019

This study aimed to explore the influence of gut microbiota alterations induced by Linderae radix ethanol extract (LREE) on alcoholic liver disease (ALD) in rats and to study the anti-inflammatory effect of LREE on ALD through the lipopolysaccharide (LPS) toll-like receptor 4 (TLR4)-nuclear factor kappa ...

Citocinas/sangre, Modelos Animales de Enfermedad, Microbioma Gastrointestinal/efectos de los fármacos, Inflamación/prevención & control, Lindera/química, Lipopolisacáridos/sangre, Hígado/ultraestructura, Hepatopatías Alcohólicas/diagnóstico por imagen, Hepatopatías Alcohólicas/prevención & control, Extractos Vegetales/farmacología, Raíces de Plantas/química, Proteínas Serina-Treonina Quinasas/sangre, Ratas Sprague-Dawley, Receptor Toll-Like 4/sangre

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Leishmania donovani infection activates Toll-like receptor 2, 4 expressions and Transforming growth factor-beta mediated apoptosis in renal tissues

Kumar, Vinod; Tiwari, Neeraj; Gedda, Mallikarjuna Rao; Haque, Rizwanul; Singh, Rakesh K.

Braz. j. infect. dis; 21 (5), 2017

Abstract The present study was aimed to identify the underlying mechanisms of improper renal function in Leishmania donovani infection that causes VL. Mice (BALB/c) were infected with L. donovani and different parameters for proteinuria were assessed. The levels of superoxide anion (O2 -), hydrogen perox...

Apoptosis, Modelos Animales de Enfermedad, Riñón/parasitología, Riñón/patología, Leishmania donovani, Leishmaniasis Visceral/sangre, Leishmaniasis Visceral/patología, Ratones Endogámicos BALB C, Receptor Toll-Like 2/sangre, Receptor Toll-Like 4/sangre, Factor de Crecimiento Transformador beta/sangre

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