TLR7 mediates increased vulnerability to ischemic acute kidney injury in diabetes
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (8), 2019
SUMMARY OBJECTIVE Diabetes is a risk factor for acute kidney injury (AKI). However, its mechanism of pathogenesis has not been elucidated. The aim of the study was to investigate the role of inflammation and the toll-like receptor 7 (TLR7) in ischemic AKI for diabetes. METHODS A high glucose hypoxia-...
Lesión Renal Aguda/metabolismo, Lesión Renal Aguda/fisiopatología, Células Cultivadas, Diabetes Mellitus/metabolismo, Diabetes Mellitus/fisiopatología, Citometría de Flujo, Isquemia/metabolismo, Isquemia/fisiopatología, ARN Interferente Pequeño, Transducción de Señal, Receptor Toll-Like 7/metabolismo, Receptor Toll-Like 7/fisiología, Transfección