LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain

Zhang, Mingxiao; Dai, Qinxue; Liang, Dongdong; Li, Dan; Chen, Sijia; Chen, Shuangdong; Han, Kunyuan; Huang, Luping; Wang, Junlu.

Arq. neuropsiquiatr; 76 (11), 2018

ABSTRACT Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation in the spinal cord. We found that an intr...

Astrocitos/efectos de los fármacos, Astrocitos/metabolismo, Modelos Animales de Enfermedad, Electroacupuntura/métodos, Inyecciones Espinales, Neuralgia/terapia, Ratas Sprague-Dawley, Receptor de Adenosina A1/administración & dosificación, Receptor de Adenosina A1/metabolismo, Nervio Ciático/lesiones, Médula Espinal/efectos de los fármacos, Médula Espinal/metabolismo, Xantinas/administración & dosificación, Xantinas/farmacología

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Caffeine teratogenicity in rats: morphological characterization and hypothesized mechanisms

Caffeine consumption during pregnancy has been shown in the scientific literature to be associated with teratogenicity such as low birth weight, fetal malformations, and miscarriage. However, the morphological alterations of the offspring of dams exposed during pregnancy have not been consistently descri...