Results: 7

Endothelial expression of the receptor for advanced glycation end products in experimental diabetes

Muñoz, Nelson; Mosquera, Jesús; Pedreañez, Adriana.

Int. j. med. surg. sci. (Print); 9 (2), 2022

The receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of several chronic diseases including diabetes. The interaction between RAGE and advanced glycation end products (AGEs) promotes gene expression, enhances the release of proinflammatory molecules and causes the gene...

Diabetes Mellitus Experimental, Receptor para Productos Finales de Glicación Avanzada/efectos de los fármacos, Losartán/farmacología, Enalapril/farmacología, Ratas Sprague-Dawley, Endotelio, Aorta Abdominal, Inmunohistoquímica, Receptor para Productos Finales de Glicación Avanzada/metabolismo, Inhibidores de la Enzima Convertidora de Angiotensina/farmacología, Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología, d0120840

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Associations of high-mobility group box 1 and receptor for advanced glycation end products with acute lung injury in patient with acute aortic dissection

Zeng, Zhaofan; Zhang, Kun; Cai, Junhong; Wu, Hongfei; Yue, Jie.

Rev. Assoc. Med. Bras. (1992, Impr.); 67 (9), 2021

SUMMARY OBJECTIVE: To investigate the associations of high-mobility group box 1 and its specific receptor, receptor for advanced glycation end products with acute lung injury in patients with acute aortic dissection. METHODS: A total of 96 acute aortic dissection patients were divided into acute aortic...

Lesión Pulmonar Aguda/etiología, Disección Aórtica, Productos Finales de Glicación Avanzada, Proteína HMGB1/metabolismo, Receptor para Productos Finales de Glicación Avanzada/metabolismo

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Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway

Yang, Lijuan; Liu, Yepei; Wang, Yuanyuan; Li, Junsheng; Liu, Na.

Clinics; 76 (), 2021

OBJECTIVES: TTP488, an antagonist of the receptor for advanced glycation end-products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). However, the mechanism underlying the protective action of TTP488 against AD has not yet been fully explored. METHODS...

Enfermedad de Alzheimer/tratamiento farmacológico, Péptidos beta-Amiloides, Imidazoles, Janus Quinasa 2, Quinasas Janus/metabolismo, Receptor para Productos Finales de Glicación Avanzada, Transducción de Señal, Transductores, Tirosina

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Papel de produtos finais de glicação avançada nas alterações hepáticas e metabólicas em modelo experimental de síndrome metabólica

Silvares, Raquel Rangel.

A doença hepática gordurosa não alcoólica (DHGNA) afeta um terço da população adulta e é definida como o acúmulo de gordura no fígado de indivíduos que não consomem excessiva quantidade de álcool. No entanto, os mecanismos moleculares responsáveis pela progressão da doença ainda não fora...

Hígado, Piridoxamina, Receptor para Productos Finales de Glicación Avanzada, Síndrome Metabólico, Hígado Graso, Enfermedad del Hígado Graso no Alcohólico

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Association between the RAGE (receptor for advanced glycation end-products) -374T/A gene polymorphism and diabetic retinopathy in T2DM

Tao, Dan; Mai, Xuancheng; Zhang, Tiesong; Mei, Yan.

Rev. Assoc. Med. Bras. (1992, Impr.); 63 (11), 2017

Summary Objective: Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological stud...

Alelos, Diabetes Mellitus Tipo 2/complicaciones, Diabetes Mellitus Tipo 2/genética, Retinopatía Diabética/etiología, Retinopatía Diabética/genética, Predisposición Genética a la Enfermedad, Genotipo, Polimorfismo Genético, Receptor para Productos Finales de Glicación Avanzada, Factores de Riesgo

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S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products

Xu, Yu-Dong; Wang, Yu; Yin, Lei-Miao; Peng, Ling-Ling; Park, Gyoung-Hee; Yang, Yong-Qing.

Biol. Res; 50 (), 2017

BACKGROUND: Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation. Here, the effect of exogenous S100A8 protein on the proliferation of ASMCs induced...

Calgranulina A/administración & dosificación, Proliferación Celular/efectos de los fármacos, Miocitos del Músculo Liso/efectos de los fármacos, Factor de Crecimiento Derivado de Plaquetas/agonistas, Receptor para Productos Finales de Glicación Avanzada/efectos de los fármacos, Células Cultivadas

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Ação da proteína amiloide sérica A em melanomas

Bellé, Luziane Potrich.

Concentrações séricas basais da proteína amiloide sérica A (SAA) estão significativamente aumentadas em pacientes com câncer e alguns autores sugerem uma relação causal. Trabalho anterior do grupo mostrou que a SAA induz a proliferação de duas linhagens de glioblastoma humano e afeta os proces...

Proteína Amiloide A Sérica/análisis, Melanoma/fisiopatología, Proteína Amiloide A Sérica/efectos adversos, Proteínas Proto-Oncogénicas B-raf/efectos adversos, Expresión Génica, Receptor Toll-Like 2/genética, Receptor Toll-Like 4/genética, Receptor para Productos Finales de Glicación Avanzada/genética, Ensayos de Migración Celular/instrumentación

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