LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Endothelial expression of the receptor for advanced glycation end products in experimental diabetes

Muñoz, Nelson; Mosquera, Jesús; Pedreañez, Adriana.

Int. j. med. surg. sci. (Print); 9 (2), 2022

The receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of several chronic diseases including diabetes. The interaction between RAGE and advanced glycation end products (AGEs) promotes gene expression, enhances the release of proinflammatory molecules and causes the gene...

Diabetes Mellitus Experimental, Receptor para Productos Finales de Glicación Avanzada/efectos de los fármacos, Losartán/farmacología, Enalapril/farmacología, Ratas Sprague-Dawley, Endotelio, Aorta Abdominal, Inmunohistoquímica, Receptor para Productos Finales de Glicación Avanzada/metabolismo, Inhibidores de la Enzima Convertidora de Angiotensina/farmacología, Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología, d0120840

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S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products

BACKGROUND: Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium-binding protein with a potential to regulate cell proliferation. Here, the effect of exogenous S100A8 protein on the proliferation of ASMCs induced...