LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Association of taste receptor gene polymorphisms with dental caries

Arid, Juliana; Antunes, Lívia Azeredo Alves; Koch, Luiza Foltran de Azevedo; Evangelista, Silvane Silva; Vasconcelos, Katia Regina Felizardo; Brancher, João Armando; Gabardo, Marilisa Carneiro Leão; Milani, Ana Julia; Dutra, André Luiz Tannus; Antunes, Leonardo Santos; Vieira, Alexandre Rezende; Feltrin-Souza, Juliana; KÜchler, Erika Calvano.

Braz. oral res. (Online); 34 (), 2020

Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescent...

Brasil/epidemiología, Índice CPO, Caries Dental/epidemiología, Caries Dental/genética, Estado Nutricional/genética, Polimorfismo Genético, Prevalencia, Reacción en Cadena en Tiempo Real de la Polimerasa, Receptores Acoplados a Proteínas G/genética, Análisis de Regresión, Factores de Riesgo, Encuestas y Cuestionarios, Gusto/genética

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The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

Norum, Jens Henrik; Skarpen, Ellen; Brech, Andreas; Kuiper, Raoul; Waaler, Jo; Krauss, Stefan; Sørlie, Therese.

Biol. Res; 51 (), 2018

Abstract Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is a known WNT pathway target gene and mark...

Proliferación Celular/efectos de los fármacos, Duodeno/efectos de los fármacos, Intestino Delgado/efectos de los fármacos, Receptores Acoplados a Proteínas G/efectos de los fármacos, Células Madre/efectos de los fármacos, Sulfonas/farmacología, Tanquirasas/antagonistas & inhibidores, Triazoles/farmacología, Duodeno/citología, Técnica del Anticuerpo Fluorescente, Inmunohistoquímica, Ratones Transgénicos, Microscopía Confocal, Receptores Acoplados a Proteínas G/genética, Sulfonas/farmacocinética, Tanquirasas/farmacocinética, Tanquirasas/farmacología, Triazoles/farmacocinética

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The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors

Ngai, Michelle; McDowell, Mary Ann.

Mem. Inst. Oswaldo Cruz; 112 (1), 2017

Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resi...

Marcación de Gen/métodos, Genoma de los Insectos, Control de Insectos/métodos, Resistencia a los Insecticidas, Insecticidas, Interferencia de ARN, Receptores Acoplados a Proteínas G/genética, Receptores Acoplados a Proteínas G/metabolismo

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