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Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Marafie, Sulaiman K; Al-Shawaf, Eman M; Abubaker, Jehad; Arefanian, Hossein.
Biol. Res; 52 (), 2019
BACKGROUND: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lead to lipotox...
Células Secretoras de Insulina/efectos de los fármacos, Metabolismo de los Lípidos/efectos de los fármacos, Ácido Palmítico/toxicidad, Proteínas Proto-Oncogénicas c-akt/metabolismo, Serina-Treonina Quinasas TOR/metabolismo, Receptores Acoplados a Proteínas G/metabolismo, Células Secretoras de Insulina/metabolismo, Apoptosis, Línea Celular, Transducción de Señal
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The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors

Ngai, Michelle; McDowell, Mary Ann.
Mem. Inst. Oswaldo Cruz; 112 (1), 2017
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resi...
Marcación de Gen/métodos, Genoma de los Insectos, Control de Insectos/métodos, Resistencia a los Insecticidas, Insecticidas, Interferencia de ARN, Receptores Acoplados a Proteínas G/genética, Receptores Acoplados a Proteínas G/metabolismo
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