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Association between beta-2 adrenergic receptor variants and clinical outcomes in children and adolescents with acute asthma

Muchão, Fábio Pereira; Souza, Andréa Vieira de; Souza, Juliana Miguita e; Silva Filho, Luiz Vicente Ribeiro Ferreira da.
Einstein (São Paulo, Online); 20 (), 2022
ABSTRACT Objective To investigate whether different genotypes of p.Arg16Gly, p.Gln27Glu, p.Arg19Cys and p.Thr164Ile variants interfere in response to treatment in children and adolescents with moderate to severe acute asthma. Methods This sample comprised patients aged 2 to 17 years with a history of...
Albuterol/uso terapéutico, Asma/tratamiento farmacológico, Asma/genética, Inhaladores de Dosis Medida, Nebulizadores y Vaporizadores, Receptores Adrenérgicos beta 2/genética, Receptores Adrenérgicos beta 2/uso terapéutico
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Genetic polymorphisms and asthma: findings from a case - control study in the Madeira island population

Berenguer, Anabela Gonçalves; Fernandes, Ana Teresa; Oliveira, Susana; Rodrigues, Mariana; Ornelas, Pedro; Romeira, Diogo; Serrão, Tânia; Rosa, Alexandra; Câmara, Rita.
Biol. Res; 47 (), 2014
BACKGROUND: Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients acco...
Asma/genética, Polimorfismo Genético/genética, Proteínas ADAM/análisis, Proteínas ADAM/genética, Desintegrinas/análisis, Desintegrinas/genética, Volumen Espiratorio Forzado/genética, Interleucina-13/análisis, Interleucina-13/genética, Interleucina-4/análisis, Interleucina-4/genética, Proteínas de Neoplasias/análisis, Proteínas de Neoplasias/genética, Polimorfismo de Nucleótido Simple/genética, Receptores Adrenérgicos beta 2/análisis, Receptores Adrenérgicos beta 2/genética, Factor de Transcripción STAT6/análisis, Factor de Transcripción STAT6/genética, Capacidad Vital/genética, Biomarcadores, Estudios de Casos y Controles, Genotipo, Portugal, Factores de Riesgo, Índice de Severidad de la Enfermedad, Estadísticas no Paramétricas
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