LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults

Lima, Raquel Patrícia Ataíde; Ribeiro, Marina Ramalho; Lima, Keylha Querino de Farias; Sena, Elisama Araújo de; Costa, Diego de Oliveira; Luna, Rafaella Cristhine Pordeus; Nascimento, Rayner Anderson Ferreira do; Gonçalves, Maria da Conceição Rodrigues; Vianna, Rodrigo Pinheiro de Toledo; Moraes, Ronei Marcos de; Oliveira, Naila Francis Paulo de; Almeida, Aléssio Tony Cavalcanti de; Costa, Maria José de Carvalho.

Biol. Res; 52 (), 2019

BACKGROUND: Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it with lipid profile, lipid intake, and oxidative stress based on malondialdehyde (M...

Metilación de ADN/fisiología, Lípidos/sangre, Obesidad/genética, Receptores Adrenérgicos beta 3/genética, Obesidad/sangre, Obesidad/metabolismo, Estudios Transversales, Ingestión de Energía, Conducta Alimentaria, Estilo de Vida, Estado Nutricional, Factores Socioeconómicos

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Trp64Arg polymorphism of the ADRB3 gene associated with maximal fat oxidation and LDL-C levels in non-obese adolescents

Abstract Objective: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates and the lipid profile levels in non-obese adolescents. Methods: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric...