LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers

Chopra, Nitin; Ruan, Can-Jun; McCollum, Betsy; Ognibene, Judy; Shelton, Charles; de Leon, Jose.

Rev. colomb. psiquiatr; 49 (2), 2020

ABSTRACT Introduction: In the last 20 years of clinical practice, the senior author has identified these 2 rare cases in which the patients needed extremely high doses of drugs metabolized by CYP3A4 to reach and maintain serum therapeutic concentrations. Methods: The high metabolic ability of these 2...

Carbamazepina, Citocromo P-450 CYP3A, Diazepam, Dosificación, Inductores del Citocromo P-450 CYP3A, Palmitato de Paliperidona, Receptores Citoplasmáticos y Nucleares, Preparaciones Farmacéuticas, Triacetonamina-N-Oxil, Risperidona, Olanzapina, Fumarato de Quetiapina, Métodos

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Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

Kobayashi, Priscila E; Rodrigues, Marcela M. P; Gartner, Fatima; Rema, Alexandra; Fonseca-Alves, Carlos E; Laufer-Amorim, Renée.

Pesqui. vet. bras; 39 (1), 2019

Canine prostate gland is a hormonal dependent organ and its imbalance of estrogen and androgen receptor expressions are directly associated with the development of different diseases. Due to the lack of information regarding the behavior of the aforementioned receptors in canine prostate cancer (PC), thi...

Receptor alfa de Estrógeno, Neoplasias de la Próstata/veterinaria, Receptores Androgénicos, Hiperplasia Prostática/veterinaria, Perros, Neoplasia Intraepitelial Prostática/veterinaria, Próstata/patología, Modelos Animales de Enfermedad, Receptores Citoplasmáticos y Nucleares, Neoplasias de la Próstata Resistentes a la Castración/veterinaria

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MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression

Xu, Jian; Wang, Yong; Yin, Jiajun; Yin, Min; Wang, Mofei; Liu, Jingang.

Braz. j. med. biol. res; 51 (7), 2018

Farnesoid X receptor (FXR) and related pathways are involved in the therapeutic effect of sleeve gastrectomy for overweight or obese patients with diabetes mellitus. This study aimed to investigate the mechanism of FXR expression regulation during the surgical treatment of obese diabetes mellitus by slee...

Western Blotting, Diabetes Mellitus Experimental/metabolismo, Gastrectomía/métodos, Regulación de la Expresión Génica, Metabolismo de los Lípidos, Hígado/metabolismo, Factor de Transcripción MafB/genética, Factor de Transcripción MafB/metabolismo, Obesidad/metabolismo, Obesidad/cirugía, Proteínas Oncogénicas/genética, Proteínas Oncogénicas/metabolismo, Ratas Sprague-Dawley, Receptores Citoplasmáticos y Nucleares/genética, Receptores Citoplasmáticos y Nucleares/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa

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