LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (

Alberto-Silva, Carlos; Pantaleão, Halyne Queiroz; Silva, Brenda Rufino da; Silva, Julio Cezar Araujo da; Echeverry, Marcela Bermudez.

J. venom. anim. toxins incl. trop. dis; 30 (), 2024

Background: The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective effects of a sy...

Receptores Muscarínicos/química, Oligopéptidos/efectos adversos, Prolina, Venenos de Crotálidos/síntesis química, Estrés Oxidativo

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Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus

Santos, Roberta Tancredi Francesco dos; Silva, Marcelo Florencio Passos; Porto, Rafael Marques; Lebrun, Ivo; Gonçalves, Luís Roberto de Camargo; Batista, Isabel de Fátima Correia; Sandoval, Maria Regina Lopes; Abdalla, Fernando Maurício Francis.

J. venom. anim. toxins incl. trop. dis; 26 (), 2020

Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). Methods: The purification, molecular mass determination, partial amino acid sequencing, phospholipase A2 activit...

Receptores Muscarínicos/análisis, Fosfolipasas A2, Serpientes, Análisis de Secuencia de Proteína, Fosfatos de Inositol, Acetilcolina, Venenos Elapídicos/efectos adversos

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Curcuma Longa Abolishes Phenylephrine-Induced Contractions in Isolated Aortic Artery of Rats

Brozzo, Natacha Pinheiro Melo; Ferreira, Efraim dos Santos; Gonçalves, Eduardo Andrade; Meneguetti, Dionatas Ulises de Oliveira; Silva, Delano Aníbal da; Cunha, Renildo Moura da.

Int. j. cardiovasc. sci. (Impr.); 32 (3), 2019

Curcuma longa has biological effects. Its cardiovascular activities are yet to be scientifically studied. Objectives: To investigate the vasorelaxant effects of the aqueous extract of Curcuma longa (AECL). Methods: Aortic annuli of normotensive rats, with or without endothelium, were set up in a data s...

Curcuma/efectos adversos, Fenilefrina, Aorta, Ratas, Modelos Animales, Crocus, Receptores Muscarínicos, Vasodilatadores/uso terapéutico, Cardiotónicos, Hipertensión, Antioxidantes, 28599, Análisis de Varianza

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Atropine is more efficient than ZM241385 to reduce a drastic level of fade caused by cisatracurium at 50 Hz

Pimentel, Arethusa Lobo; Prado, Gabriela de Castro; Alves-Do-Prado, Wilson; Ambiel, Célia Regina.

Acta sci., Health sci; 38 (2), 2016

The effects of atropine (non selective muscarinic antagonist) and ZM241385 (A2A receptors antagonist) in the cisatracurium-induced drastic (100%) level of fade at 50 Hz (10 s) (100% Fade) were compared in the phrenic nerve-diaphragm muscle preparations of rats indirectly stimulated at a physiological tet...

Fatiga Muscular, Adenosina, Receptores Muscarínicos, Bloqueantes Neuromusculares, Atropina

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