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Results: 4

Cochlea cell-specific marker expression upon in vitro Hes1 knockdown

Batissoco, A C; Lezirovitz, K; Zanatta, D B; Hemza, C R M L; Vasques, L R; Strauss, B E; Mingroni-Netto, R C; Haddad, L A; Bento, R F; Oiticica, J.
Braz. j. med. biol. res; 54 (7), 2021
NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from becoming hair cells. Genetic manipulation of this ...
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Diferenciación Celular, Cóclea, Células Ciliadas Auditivas, Órgano Espiral, Receptores Notch, Factor de Transcripción HES-1/genética
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Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment

Zhu, Qing; Li, Jingchao; Wu, Qi; Cheng, Yongxia; Zheng, Huizhe; Zhan, Tao; Wang, Hongwei; Yang, Yue; Wang, Hongyan; Liu, Ye; Guo, Sufen.
Biol. Res; 53 (), 2020
BACKGROUND: LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs...
Proteínas Adaptadoras Transductoras de Señales/metabolismo, Neoplasias de la Mama/patología, Células Endoteliales de la Vena Umbilical Humana/citología, Neuropilina-1/metabolismo, Receptores Notch/metabolismo, Factores de Transcripción/metabolismo, Microambiente Tumoral, Neoplasias de la Mama/metabolismo, Western Blotting, Línea Celular Tumoral, Inmunohistoquímica, Reacción en Cadena en Tiempo Real de la Polimerasa, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Transducción de Señal
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Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway

Yao, Yi En; Zhang, Jing Hong; Chen, Xiao Ju; Huang, Jian Lin; Sun, Qi Xiang; Liu, Wei Wei; Zeng, Huan; Li, Chao Qian.
Braz. j. med. biol. res; 53 (11), 2020
The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (γδT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin (OVA). Gamma-secretase inhibitor (DAPT) was used to block the Notch signal...
Proteína Jagged-1, Mycobacterium, Ovalbúmina, Receptores Notch, Transducción de Señal
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