Cruz, Matheus Loureiro da Silva;
Santos, Rafael Pereira dos;
Souza, Barbara Kunzler;
Jaeger, Mariane da Cunha;
Silva, Camila Alves da;
Gregianin, Lauro José;
Loss, Jiseh Fagundes;
Marques, Rebeca Ferreira;
Brunetto, Algemir Lunardi;
Brunetto, André Tesainer;
Roesler, Rafael;
Farias, Caroline Brunetto de.
Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric
leukemias. Novel targets are necessary to improve survival rates for refractory and relapsed disease. There is accumulating evidence that
Toll-like Receptor (TLR) signaling may be a...
Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a ...
Brandão, Simone Cristina Soares;
Godoi, Emmanuelle Tenório Albuquerque Madruga;
Cordeiro, Lúcia Helena de Oliveira;
Lima, Débora Nóbrega de;
Medeiros, Camila de Holanda;
Albuquerque, João Paulo Vieira e Silva de;
Ramos, Maria Eduarda Lins Arraes;
Albêlo, Romero Carvalho Coimbra;
Matos, Maria Fernanda Peixoto;
Sarinho, Emanuel Sávio Cavalcanti.
No combate à infecção pelo coronavírus 2 da síndrome respiratória aguda grave (SARS-CoV-2), o organismo se utiliza de mecanismos da imunidade inata, dentre eles os receptores Toll- Like (TLR), responsáveis pela sinalização da inflamação através da liberação de mediadores químicos e recruta...
COVID-19/fisiopatología,
Enzima Convertidora de Angiotensina 2,
COVID-19,
Aterosclerosis,
Diabetes Mellitus,
Hipertensión,
Obesidad,
Pacientes,
Patología,
Pronóstico,
Receptores Toll-Like,
SARS-CoV-2,
Sistema Inmunológico,
Terapéutica,
Virus,
Sistema Renina-Angiotensina
Resumen La hidroxicloroquina es un antiguo fármaco proveniente del árbol de quino (Cinchona pubescens), a partir del componente químico alcaloide llamado quinina. Sus primeros usos se documentaron en el Imperio Inca del Perú. Se caracteriza por distintos efectos beneficiosos en enfermedades inmunoló...
ABSTRACT Objective To analyze and compare the expression of Toll-like receptors by regulatory T cells present in the peritoneal fluid of patients with and without endometriosis. Methods Regulatory T cells were isolated from peritoneal fluid of women with and without endometriosis, collected during su...
Líquido Ascítico/inmunología,
Líquido Ascítico/patología,
Índice de Masa Corporal,
Estudios de Casos y Controles,
Endometriosis/inmunología,
Endometriosis/patología,
Endometrio/inmunología,
Endometrio/patología,
Valores de Referencia,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Estadísticas no Paramétricas,
Linfocitos T Reguladores/química,
Linfocitos T Reguladores/inmunología,
Receptores Toll-Like/análisis,
Escala Visual Analógica
Inflammation plays an important role in the development of cardiovascular diseases (CVDs), suggesting that the immune system is a target of therapeutic interventions used for treating CVDs. This study evaluated mechanisms underlying inflammatory response and cardiomyocyte hypertrophy associated with bact...
Proteína Quinasa Tipo 2 Dependiente de Calcio Calmodulina/metabolismo,
Chaperonina 60/farmacología,
Expresión Génica,
Inflamación/metabolismo,
Lipopolisacáridos/farmacología,
Miocitos Cardíacos/efectos de los fármacos,
Miocitos Cardíacos/metabolismo,
Miocitos Cardíacos/patología,
FN-kappa B/metabolismo,
ARN Interferente Pequeño,
Ratas Wistar,
Transducción de Señal/fisiología,
Receptores Toll-Like/metabolismo
Abstract Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. We investigated the per...
Abstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning ...
Background: Peptidoglycan (PGN) recognition proteins (PGRPs) are important pattern recognition receptors of the host innate immune system that are involved in the immune defense against bacterial pathogens. PGRPs have been characterized in several fish species. The PGN-binding ability is important for th...
Peces Planos/inmunología,
Peces Planos/genética,
Lengua/inmunología,
Proteínas Portadoras,
Ligandos,
Sitios de Unión,
Peces Planos/metabolismo,
Simulación de Dinámica Molecular,
Receptores Toll-Like,
Peptidoglicano,
Simulación del Acoplamiento Molecular
