Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the ...
SUMMARY OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL...
Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms of the vitamin D receptor (VDR) gene may help elucidate the pathogenesis of CD. Objectives: To analyze the role of VDR gene polymorphisms...
The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, a...
Silva-Sousa, Alice Corrêa;
Mazzi-Chaves, Jardel Francisco;
Freitas, Jessica Vavassori;
Salles, Alessandro Guimarães;
Segato, Raquel Assed Bezerra da Silva;
Silva, Léa Assed Bezerra da;
Antunes, Lívia Azeredo Alves;
Antunes, Leonardo Santos;
Baratto-Filho, Flares;
Sousa-Neto, Manoel Damião;
Küchler, Erika Calvano.
Abstract This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who ...
Receptor alfa de Estrógeno/genética,
Receptor beta de Estrógeno/genética,
Estrógenos,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Haplotipos,
MicroARNs/genética,
Polimorfismo Genético,
Polimorfismo de Nucleótido Simple,
Receptores de Calcitriol/genética,
Vitamina D
Abstract Objective: To analyze whether the FokI polymorphism (rs228570) present in the vitamin D receptor gene in type 2 diabetics is related to chronic periodontitis's clinical status and evaluates the influence of chronic periodontitis on the perception of quality of life. Material and Methods: It is...
Brasil,
Diabetes Mellitus Tipo 2/diagnóstico,
Periodontitis Crónica/patología,
Calidad de Vida,
Polimorfismo Genético,
Estadísticas no Paramétricas,
Distribución de Chi-Cuadrado,
Salud Bucal,
Periodontitis/patología,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Receptores de Calcitriol
Abstract Evidence suggests that polymorphisms in the gene encoding a vitamin D receptor might affect blood pressure. The objective of this systematic review was to investigate the association between hypertension and vitamin D receptor (Fok I) gene polymorphism. A literature search was performed accordin...
ABSTRACT Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D r...
Enfermedades del Sistema Nervioso Autónomo/sangre,
Enfermedades del Sistema Nervioso Autónomo/fisiopatología,
Presión Sanguínea/fisiología,
Estudios de Casos y Controles,
Estudios Transversales,
Ensayo de Inmunoadsorción Enzimática,
Frecuencia Cardíaca/fisiología,
Hipertensión/sangre,
Hipertensión/fisiopatología,
Hipotensión Ortostática/sangre,
Hipotensión Ortostática/fisiopatología,
Esclerosis Múltiple Recurrente-Remitente/sangre,
Esclerosis Múltiple Recurrente-Remitente/fisiopatología,
Disautonomías Primarias/sangre,
Disautonomías Primarias/etiología,
Disautonomías Primarias/fisiopatología,
Receptores de Calcitriol/sangre,
Valores de Referencia,
Factores de Riesgo,
Estadísticas no Paramétricas,
Posición Supina/fisiología,
Vitamina D/sangre,
Deficiencia de Vitamina D/sangre,
Deficiencia de Vitamina D/complicaciones,
Proteína de Unión a Vitamina D/sangre
Abstract Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and ...
Brasil,
Estudios de Casos y Controles,
Diabetes Gestacional/sangre,
Diabetes Gestacional/genética,
Predisposición Genética a la Enfermedad,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Polimorfismo de Longitud del Fragmento de Restricción,
Atención Prenatal,
Estudios Prospectivos,
Receptores de Calcitriol/genética,
Vitamina D/genética
Abstract INTRODUCTION: Chagas disease (CD) is an important public health problem in Brazil and worldwide. Aging and obesity are important matters in patients with CD, as is hypovitaminosis D3, which can decrease the quality of life of these patients. Immunomodulation mediated by vitamin D3, especially ...
