Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the ...
SUMMARY OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL...
Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms of the vitamin D receptor (VDR) gene may help elucidate the pathogenesis of CD. Objectives: To analyze the role of VDR gene polymorphisms...
The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, a...
Silva-Sousa, Alice Corrêa;
Mazzi-Chaves, Jardel Francisco;
Freitas, Jessica Vavassori;
Salles, Alessandro Guimarães;
Segato, Raquel Assed Bezerra da Silva;
Silva, Léa Assed Bezerra da;
Antunes, Lívia Azeredo Alves;
Antunes, Leonardo Santos;
Baratto-Filho, Flares;
Sousa-Neto, Manoel Damião;
Küchler, Erika Calvano.
Abstract This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who ...
Receptor alfa de Estrógeno/genética,
Receptor beta de Estrógeno/genética,
Estrógenos,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Haplotipos,
MicroARNs/genética,
Polimorfismo Genético,
Polimorfismo de Nucleótido Simple,
Receptores de Calcitriol/genética,
Vitamina D
Abstract Evidence suggests that polymorphisms in the gene encoding a vitamin D receptor might affect blood pressure. The objective of this systematic review was to investigate the association between hypertension and vitamin D receptor (Fok I) gene polymorphism. A literature search was performed accordin...
Abstract Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and ...
Brasil,
Estudios de Casos y Controles,
Diabetes Gestacional/sangre,
Diabetes Gestacional/genética,
Predisposición Genética a la Enfermedad,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Polimorfismo de Longitud del Fragmento de Restricción,
Atención Prenatal,
Estudios Prospectivos,
Receptores de Calcitriol/genética,
Vitamina D/genética
Abstract INTRODUCTION: Chagas disease (CD) is an important public health problem in Brazil and worldwide. Aging and obesity are important matters in patients with CD, as is hypovitaminosis D3, which can decrease the quality of life of these patients. Immunomodulation mediated by vitamin D3, especially ...
Oliveira, Ana Carolina R de;
Magalhães, Carolina A;
Loures, Cristina M G;
Fraga, Vanessa G;
Souza, Leonardo C de;
Guimarães, Henrique C;
Cintra, Marco T G;
Bicalho, Maria A;
Sousa, Maira C R;
Silveira, Josianne N;
Silva, Ieda F O;
Caramelli, Paulo;
Carvalho, Maria G;
Gomes, Karina B.
ABSTRACT Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. Most of the biological actions of VitD are mediated by the vitamin D receptor (VDR), which is present in neurons and glial cells of the hippocampus, and in the cortex...
RESUMO Objetivo: Verificar a relação dos polimorfismos do gene do receptor de vitamina D (RVD) com sinais clínicos e níveis de vitamina D (VD) em asmáticos. Métodos: Estudo transversal com 77 crianças de 7 a 14 anos de um ambulatório especializado, divididas em 3 grupos: asmáticos, em uso de...
