LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Phytohormone abscisic acid boosts pentobarbital-induced sleep through activation of GABA-A, PPARβ and PPARγ receptor signaling

ABSTRACT Background: Sleep disorders induce anxiety and forgetfulness and change habits. The chemical hypnotic drugs currently used have serious side effects and, therefore, people are drawn towards using natural compounds such as plant-based healing agents. Abscisic acid (ABA) is produced in a variety...

Cancer Stem Cells are Depolarized Relative to Normal Stem Cells Derived from Human Livers

Bautista, Wendy; Lipschitz, Jeremy; McKay, Andrew; Minuk, Gerald Y.

Ann. hepatol; 16 (2), 2017

ABSTRACT Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC). The aim of this study was to document and compare cell membrane potential differences (PDs) of CS...

Carcinoma Hepatocelular/metabolismo, Neoplasias Hepáticas/metabolismo, Hígado/citología, Células Madre Neoplásicas/metabolismo, Receptores de GABA-A/metabolismo, Carcinoma Hepatocelular/genética, Molécula de Adhesión Celular Epitelial/metabolismo, Agonistas de Receptores de GABA-A/farmacología, Biomarcadores/metabolismo, Técnica del Anticuerpo Fluorescente, Separación Inmunomagnética, Neoplasias Hepáticas/genética, Potenciales de la Membrana/efectos de los fármacos, Células Madre Neoplásicas/efectos de los fármacos, Fenotipo, Subunidades de Proteína, ARN Mensajero/genética, ARN Mensajero/metabolismo, Receptores de GABA-A/efectos de los fármacos, Receptores de GABA-A/genética, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Células Madre/efectos de los fármacos

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