A Esclerose Lateral Amiotrófica (ELA), uma doença neurodegenerativa
fatal, que afeta neurônios motores superiores e inferiores, tem como
fisiopatologia mais aceita a excitotoxicidade mediada por glutamato.
O atual estudo tem como objetivo estabelecer a relação entre esse
neurotransmissor e a ELA, a ...
Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) is potentially implicated in vitiligo development and progression. It was recently discovered that metabotropic glutamate receptor 4 (mGluR4) can m...
Abstract Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss, there is no report, till date, about the as...
BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic...
