LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism

ABSTRACT Alcohol consumption aggravates injuries caused by ischemia. Many molecular mechanisms are involved in the pathophysiology of cerebral ischemia, including neurotransmitter expression, which is regulated by microRNAs. Objective: To evaluate the microRNA-219 and NMDA expression in brain tissue and...

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Koriauli, S; Natsvlishvili, N; Barbakadze, T; Mikeladze, D.

Biol. Res; 48 (), 2015

BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced b...

Encéfalo/metabolismo, Ácido Glutámico/metabolismo, Interleucina-10/genética, NADPH Oxidasas/metabolismo, Receptores sigma/metabolismo, Membrana Celular/metabolismo, Retículo Endoplásmico/metabolismo, Proteínas de Choque Térmico/metabolismo, Receptores de Inositol 1,4,5-Trifosfato/metabolismo, Neuronas/metabolismo, Especies Reactivas de Oxígeno/análisis, Especies Reactivas de Oxígeno/metabolismo, Receptores de N-Metil-D-Aspartato/metabolismo, Receptores de N-Metil-D-Aspartato/clasificación, Receptores sigma/agonistas, Receptores sigma/clasificación, Proteína de Unión al GTP rac1/metabolismo, Técnicas de Silenciamiento del Gen, Inmunoprecipitación, Ratones Endogámicos C57BL

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